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merck millipore,默克密理博,203881,CR8, (R)-Isomer - CAS 294646-77-8 - Calbiochem
产品名称：CR8, (R)-Isomer - CAS 294646-77-8 - Calbiochem
产品型号：203881
A cell-permeable (R)-DRF053 analog that acts as an ATP-binding pocket-targeting CDK/CK1 dual-specific inhibitor.
merck millipore,默克密理博,203881,CR8, (R)-Isomer - CAS 294646-77-8 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₄H₂₉N₇O 294646-77-8 描述 概述 A cell-permeable (R)-DRF053 (Cat. No. 219494) analog that acts as an ATP-binding pocket-targeting CDK/CK1 dual-specific inhibitor (IC50 = 0.09, 0.072, 0.041, 0.11, 1.10, 0.18, and 0.40 µM against CDK1/B, CDK2/A, CDK2/E, CDK5/p25, CDK7/H, CDK9/T, and CK1δ/ε, respectively). As is the case with (R)-DRF053, (R)-CR8 inhibits CDK/CK1 more effectively than (R)-Roscovitine (Cat. Nos. 550360 & 550364), while maintaining similar selectivity profile over other types of kinases (IC50 = 3.6, 3.6, and 12.0 µM against Dyrk1A, Erk2, and GSK-3α/β, respectively). Both the (R)-CR8 and (S)-enantiomer (Cat. No. 203882) are much more effective than (R)-Roscovitine in apoptosis induction in cell cultures. 产品目录编号 203881 品牌系列 Calbiochem®
同义词 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine, (R)-CR8, Cdk7 Inhibitor VII 参考 参考 Oumata, N., et al. J. Med. Chem. 51, 5229.
Bettayeb, K., et al. 2008. Oncogene 27, 5797.产品信息 CAS号 294646-77-8 形式 Off-white solid Hill配方 C₂₄H₂₉N₇O 化学配方 C₂₄H₂₉N₇O Molar Mass 431.5 结构配方图像 生物信息 纯度 ≥97% by HPLC 理化信息 溶解度 DMSO or EtOH 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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