merck millipore,默克密理愽
  • merck millipore,默克密理博,401251,IM-412 - Calbiochem

  • merck millipore,默克密理博,401251,IM-412 - Calbiochem

    产品名称：IM-412 - Calbiochem
    产品型号：401251
    IM-412 primarily used in Inhibition.

    merck millipore,默克密理博,401251,IM-412 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,401251,IM-412 - Calbiochem

    重要规格表

    经验配方
    C₁₆H₁₄ClN₅O₂
    描述
    概述 A cell permeable imidazoxanthine shown to decrease TGF-β stimulated reporter activity in a dose-dependent manner in HEK293 reporter cells, with an IC50 of 4.1 µM without cell cytotoxicity. Inhibits TGF-β receptor I (TβRI) and TGF-β receptor II (TβRII) expression and its downstream Smad2 and Smad3 phosphorylation as well as JNK and ERK activity. In addition, it elicits TGF-β-induced fibroblast differentiation with attenuated expression of several fibrotic markers such as α-SMA and fibronectin, and suppresses collagen accumulation in CCD-18Lu human normal lung fibroblasts.
    产品目录编号 401251
    品牌系列 Calbiochem®
    同义词 3-(2-chlorobenzyl)-1,7-dimethyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione, TGF beta Inhibitor, IM-412
    参考
    参考 Park, S., et al. 2010. Biochem. Biophy. Res. Comm. 399, 268.
    产品信息
    形式 Off-white solid
    Hill配方 C₁₆H₁₄ClN₅O₂
    化学配方 C₁₆H₁₄ClN₅O₂
    Molar Mass 343.77
    结构配方图像
    生物信息
    纯度 ≥90% by HPLC
    理化信息
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

    merck millipore,默克密理博,401251,IM-412 - Calbiochem

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