merck millipore,默克密理愽
  • merck millipore,默克密理博,324759,Elastase Inhibitor IV - CAS 127373-66-4 - Calbiochem

  • merck millipore,默克密理博,324759,Elastase Inhibitor IV - CAS 127373-66-4 - Calbiochem

    产品名称：Elastase Inhibitor IV - CAS 127373-66-4 - Calbiochem
    产品型号：324759
    The Elastase Inhibitor IV, also referenced under CAS 127373-66-4, controls the biological activity of Elastase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

    merck millipore,默克密理博,324759,Elastase Inhibitor IV - CAS 127373-66-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,324759,Elastase Inhibitor IV - CAS 127373-66-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₀H₂₂N₂O₇S127373-66-4
    描述
    概述 A cell-permeable sulfanilide compound that acts as a potent, substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC50 = 19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase). Displays >100-fold greater selectivity over pancreas elastase (IC50 = 5.6 µM). Does not inhibit trypsin, thrombin, plasmin, kallikrein, chymotrypsin, and cathepsin G even at concentrations as high as 100 µM. Effectively suppresses human neutrophil elastase-induced lung hemorrhage and skin capillary permeability in vivo. Also reported to inhibit mast cell Stat6-protease.
    产品目录编号 324759
    品牌系列 Calbiochem®
    同义词 N-(o-(p-Pivaloyloxybenzene)sulfonylaminobenzoyl)glycine, N-(2-(4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid
    参考
    参考 Suzuki, K., et al. 2003. Biochem. Biophys. Res. Commun. 309, 768.
    Kawabata, K., et al. 1991. Biochem. Biophys. Res. Commun. 177, 814.
    产品信息
    CAS号 127373-66-4
    具有ATP竞争性 N
    形式 Yellow solid
    Hill配方 C₂₀H₂₂N₂O₇S
    化学配方 C₂₀H₂₂N₂O₇S
    Molar Mass 434.5
    可逆 N
    结构配方图像
    生物信息
    主靶 Neutrophil elastase
    主靶IC50 19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,324759,Elastase Inhibitor IV - CAS 127373-66-4 - Calbiochem

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