merck millipore,默克密理愽
  • merck millipore,默克密理博,681669,Wnt Antagonist I, IWR-1-endo - Calbiochem

  • merck millipore,默克密理博,681669,Wnt Antagonist I, IWR-1-endo - Calbiochem

    产品名称：Wnt Antagonist I, IWR-1-endo - Calbiochem
    产品型号：681669
    The Wnt Antagonist I, IWR-1-endo controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.

    merck millipore,默克密理博,681669,Wnt Antagonist I, IWR-1-endo - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,681669,Wnt Antagonist I, IWR-1-endo - Calbiochem

    重要规格表

    经验配方
    C₂₅H₁₉N₃O₃
    描述
    概述 A cell-permeable p-imidobenzamidoquinoline, endo-diastereomer that is shown to inhibit the activity of TNKS1/PARP5a and TNKS2/PARP5b in in vitro auto-PARsylation assays (IC50 = 131 and 56 nM, respectively) and effectively suppress Wnt-stimulated transcription activity in L-Wnt-STF-based reporter assays (IC50 = 180 nM), while exhibiting little activity against PARP1 or PARP2 (IC50 >18.75 µM). Although both IWR-1-endo and XAV939 act as reversible Wnt pathway inhibitors and exhibit similar pharmacological effects both in vitro and in vivo, IWR-1-endo exerts its effect via interaction with Axin, while XAV939 binds TNKS directly. Also available as a 25 mM solution in DMSO (Cat. No. 504462).
    产品目录编号 681669
    品牌系列 Calbiochem®
    同义词 Inhibitor of Wnt Response-1, Wnt Pathway Inhibitor I, TNKS1/2 Inhibitor II, Tankyrase1/2 Inhibitor II
    参考
    参考 Chen, B., et al. 2009. Nature Chem. Biol. 5, 100.
    Huang, S.M., et al. 2009. Nature 461, 614.
    产品信息
    形式 Off-white solid
    Hill配方 C₂₅H₁₉N₃O₃
    化学配方 C₂₅H₁₉N₃O₃
    Molar Mass 409.4
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,681669,Wnt Antagonist I, IWR-1-endo - Calbiochem

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