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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, ELISA M Purified Monoclonal Antibody 描述 产品目录编号 MAB3774 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Annexin II Antibody, clone 3D5/4 Alternate Names - Lipocortin II, Calpactin I Heavy Chain, Chromobindin 8
- Lipocortin II
- Calpactin I Heavy Chain
背景信息 Annexin II belongs to a family of Ca2+ dependent phospholipid binding proteins. It is thought to serve as a profibrinolytic coreceptor for both plasminogen and tissue plasminogen activator on the surface of endothelial cells. It is also known to interact with viral pathogens. 产品信息 格式 Purified 演示 Purified immunoglobulin. Liquid in 0.02M phosphate buffer, 0.25M NaCl, pH 7.6, with 0.1% sodium azide 应用 应用 Detect Annexin II using this Anti-Annexin II Antibody, clone 3D5/4 validated for use in ELISA, IP, IH. 主要应用 - Immunohistochemistry
- ELISA
应用说明 Immunoprecipitation
Immunohistochemistry: acetone fixed frozen sections
ELISA
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Whole native annexin proteins contained in a mixture of membrane proteins from human bone tissue 克隆 3D5/4 宿主 Mouse 特异性 Recognizes human Annexin II 同种型 IgG2a 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_004039.2
- NM_001002857.1
- NM_001002858.1
Entrez基因汇总 This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. 基因符号 - CAL1H
- ANXA2
- LPC2D
- P36
- p36
- Chromobindin-8
- LIP2
- Annexin-2
- ANX2L4
- LPC2
- ANX2
- PAP-IV
UniProt编号 - P07355
UniProt汇总 FUNCTION: SwissProt: P07355 # Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.
SIZE: 339 amino acids; 38604 Da
SUBUNIT: Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36.
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome. Note=In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.
DOMAIN: SwissProt: P07355 A pair of annexin repeats may form one binding site for calcium and phospholipid.
PTM: Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface.
SIMILARITY: Belongs to the annexin family. & Contains 4 annexin repeats.
MISCELLANEOUS: It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C in undiluted aliquots for up to 12 months from date of receipt. 包装信息 数量 100 µg
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