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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H, M IHC, WB, ICC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABN464 描述 Anti-IRE1p Antibody Alternate Names - IRE1a
- Endoplasmic reticulum-to-nucleus signaling 1
- Serine/threonine-protein kinase/endoribonuclease IRE1
- ERN1
- IRE1
- Inositol-requiring protein 1
- hIRE1p
- Ire1-alpha
背景信息 Inositol-requiring protein 1 (IRE1p), also known as Ire1-alpha (IRE1a), Endoplasmic reticulum-to-nucleus signaling 1 (ERN1), and Serine/threonine-protein kinase/endoribonuclease IRE1, contains 1 KEN domain and 1 protein kinase domain.
IRE1p has an endoribonuclease activity that is required to splice X-box binding protein (XBP1) mRNA converting it to a potent UPR transcriptional activation. Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER. IRE1p is ubiquitously expressed with high levels observed in pancreatic tissue.产品信息 格式 Affinity Purified 控制 - A20 cell lysate
演示 Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. 应用 应用 Detect Inositol-requiring protein 1 using this rabbit polyclonal antibody, Anti-IRE1p Antibody validated for use in western blotting, ICC & IHC. 主要应用 - Immunohistochemistry
- Western Blotting
- Immunocytochemistry
应用说明 Immunohistchemistry Analysis: A 1:1,000 dilution from a representative lot detected IRE1p in human pancreas and kidney tissues.
Immunocytochemistry Analysis: 1 µg/mL from a representative lot detected IRE1p in A20 cells.
Immunofluorescence Analysis: 2 µg/mL from a representative lot detected IRE1p in A20 cells.生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the C-terminus of human IRE1p. 表位 C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes the C-terminus of IRE1p. 品种反应性 HumanMouse 抗体类型 Polyclonal Antibody 基因符号 - IREp1
- ERN1
纯化方法 Antigen Affinity purified UniProt编号 - O75460
产品使用声明 质量保证 Evaluated by Western Blotting in A20 cell lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected IRE1p in A20 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,AB2036,Anti-Collagen Type II Antibody
下一件merck millipore产品：merck millipore,默克密理博,AG281-100UL,Adenosine A2a Receptor Positive Control
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