merck millipore,默克密理愽
  • merck millipore,默克密理博,676481,VEGFR Tyrosine Kinase Inhibitor II - CAS 269390-69-4 - Calbiochem

  • merck millipore,默克密理博,676481,VEGFR Tyrosine Kinase Inhibitor II - CAS 269390-69-4 - Calbiochem

    产品名称：VEGFR Tyrosine Kinase Inhibitor II - CAS 269390-69-4 - Calbiochem
    产品型号：676481
    The VEGFR Tyrosine Kinase Inhibitor II, also referenced under CAS 269390-69-4, controls the biological activity of VEGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphoryl More>>

    merck millipore,默克密理博,676481,VEGFR Tyrosine Kinase Inhibitor II - CAS 269390-69-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,676481,VEGFR Tyrosine Kinase Inhibitor II - CAS 269390-69-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₉H₁₆ClN₃O269390-69-4
    描述
    概述 A pyridinyl-anthranilamide compound that displays both antiangiogenic and antitumor properties. A potent, cell-permeable, reversible, and ATP-competitive inhibitor of the kinase activities of KDR, Flt-1 and c-Kit (IC50 = 20 nM, 180 nM and 240 nM, respectively), and minimally inhibit c-Src and EGF-R activities (IC50 = 7 µM and 7.3 µM). Further, inactive towards the inhibition of CDK-1, c-Met, IGF-1R and PKA (IC50 > 10 µM).
    产品目录编号 676481
    品牌系列 Calbiochem®
    同义词 N-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide, VEGF Receptor Tyrosine Kinase Inhibitor II, VEGFR2 Kinase Inhibitor XVII, VEGFR1 Kinase Inhibitor III
    参考
    参考 Furet, P., et al. 2003. Bioorg. Med. Chem. Lett. 13, 2967.
    产品信息
    CAS号 269390-69-4
    具有ATP竞争性 Y
    形式 White solid
    Hill配方 C₁₉H₁₆ClN₃O
    化学配方 C₁₉H₁₆ClN₃O
    Molar Mass 337.8
    可逆 Y
    结构配方图像
    生物信息
    主靶 Kinase activities of KDR, Flt-1 and c-Kit
    主靶IC50 20 nM, 180 nM and 240 nM against kinase activities of KDR, Flt-1 and c-Kit, respectively
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or MeOH
    储存和货运信息
    货运代码 Blue Ice Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,676481,VEGFR Tyrosine Kinase Inhibitor II - CAS 269390-69-4 - Calbiochem

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