merck millipore,默克密理愽
  • merck millipore,默克密理博,553502,Rac1 Inhibitor - CAS 1177865-17-6 - Calbiochem

  • merck millipore,默克密理博,553502,Rac1 Inhibitor - CAS 1177865-17-6 - Calbiochem

    产品名称：Rac1 Inhibitor - CAS 1177865-17-6 - Calbiochem
    产品型号：553502
    The Rac1 Inhibitor, also referenced under CAS 1177865-17-6, controls the biological activity of Rac1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applicatio More>>

    merck millipore,默克密理博,553502,Rac1 Inhibitor - CAS 1177865-17-6 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,553502,Rac1 Inhibitor - CAS 1177865-17-6 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₄H₃₈Cl₃N₇1177865-17-6
    描述
    概述 A cell-permeable pyrimidine compound that specifically and reversibly inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC50 ~50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 μM). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1. Reduces TRAP-induced and collagen stimulated platelet aggregation (IC50 = 50 mM and 64 mM, respectively).
    产品目录编号 553502
    品牌系列 Calbiochem®
    同义词 NSC23766
    参考
    参考 Dwivedi, S., et al. 2010. J. Translational Med. 8, 128.
    Desire, L., et al. 2005. J. Biol. Chem. 280, 37516.
    Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.
    产品信息
    CAS号 1177865-17-6
    具有ATP竞争性 N
    形式 Lyophilized
    Hill配方 C₂₄H₃₈Cl₃N₇
    化学配方 C₂₄H₃₈Cl₃N₇
    Molar Mass 530.96
    吸湿 Hygroscopic
    可逆 Y
    结构配方图像
    生物信息
    主靶 Rac1
    主靶IC50 ~50 µM against Rac1 GDP/GTP exchange activity; 50 mM and 64 mM against TRAP-induced and collagen stimulated platelet aggregation
    纯度 ≥93% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 H₂O
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Carcinogenic / Teratogenic
    储存 +2°C to +8°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,553502,Rac1 Inhibitor - CAS 1177865-17-6 - Calbiochem

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