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merck millipore,默克密理博,609315,Thyroid Hormone Receptor Antagonist, 1-850 - CAS 251310-57-3 - Calbiochem
产品名称：Thyroid Hormone Receptor Antagonist, 1-850 - CAS 251310-57-3 - Calbiochem
产品型号：609315
The Thyroid Hormone Receptor Antagonist, 1-850, also referenced under CAS 251310-57-3, controls the biological activity of Thyroid Hormone Receptor. This small molecule/inhibitor is primarily used for More>>
merck millipore,默克密理博,609315,Thyroid Hormone Receptor Antagonist, 1-850 - CAS 251310-57-3 - Calbiochem
- 产品介绍
- merck millipore,默克密理博,609315,Thyroid Hormone Receptor Antagonist, 1-850 - CAS 251310-57-3 - Calbiochem
重要规格表
经验配方 CAS号 C₂₁H₂₀F₃N₅O₄ 251310-57-3 描述 概述 A cell-permeable hydrazinyl-carboxamide compound that acts as a selective and high-affinity thyroid hormone receptor (TR) antagonist (IC50 = 1.5 µM in HeLa cells). Shown to block T3- (L-triiodothyronine) mediated interaction of TRα with NRC (nuclear receptor coactivator) and prevent the stimulation of gene expression. Exerts no effect on the retinoic acid receptor α (RARα) activity. 产品目录编号 609315 品牌系列 Calbiochem®
同义词 TR Antagonist, 1-850, 2-(2-(-(4-Nitrophenyl)-4-piperidinylidene)acetyl-N-(3-(trifluoromethyl)phenyl)-1-hydrazine Carboxamide 参考 参考 Schapira, M., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7354. 产品信息 CAS号 251310-57-3 具有ATP竞争性 N 形式 Yellow solid Hill配方 C₂₁H₂₀F₃N₅O₄ 化学配方 C₂₁H₂₀F₃N₅O₄ Molar Mass 463.4 可逆 N 结构配方图像 生物信息 主靶 Thyroid Hormone Receptor 主靶IC50 1.5 µM as antagonist for thyroid hormone receptor (TR) in HeLa cells 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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