merck millipore,默克密理愽
  • merck millipore,默克密理博,MABT61,Anti-Nectin-1/PVRL1 (CD111) Antibody, clone R1.302

  • merck millipore,默克密理博,MABT61,Anti-Nectin-1/PVRL1 (CD111) Antibody, clone R1.302

    产品名称：Anti-Nectin-1/PVRL1 (CD111) Antibody, clone R1.302
    产品型号：MABT61
    This Anti-Nectin-1/PVRL1 (CD111) Antibody, clone R1.302 is validated for use in FC, IF for the detection of Nectin-1/PVRL1 (CD111).

    merck millipore,默克密理博,MABT61,Anti-Nectin-1/PVRL1 (CD111) Antibody, clone R1.302

  • 产品介绍
  • merck millipore,默克密理博,MABT61,Anti-Nectin-1/PVRL1 (CD111) Antibody, clone R1.302

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABT61
    描述 Anti-Nectin-1/PVRL1 (CD111) Antibody, clone R1.302
    Alternate Names
    • CD111 antigen
    • poliovirus receptor-related 1 (herpesvirus entry mediator C)
    • nectin-1
    • poliovirus receptor-related protein 1
    • poliovirus receptor-like 1
    • nectin 1
    • ectodermal dysplasia 4 (Margarita Island type)
    • Herpesvirus entry mediator C
    • Herpes virus entry mediator C
    • Nectin-1
    • Herpesvirus Ig-like receptor
    背景信息 Nectin-1, also known as poliovirus receptor-related protein 1 (PRR1 or PVRL1) or CD111, is an immunoglobulin-like transmembrane cell adhesion protein that also seems to play a role in neural tube formation, with N-cadherin. Nectins are known for being the receptors for the herpes simplex virus. Nectin-1 is connected with the actin cytoskeleton through afadin inside the cell. It is predominantly found in human placenta although in mice, expression is wide-ranging. Nectin-1 seems to adhere primarily to cells expressing nectin-4 and vice versa.
    产品信息
    格式 Purified
    控制
    • Human TF-1 cells
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Anti-Nectin-1/PVRL1 (CD111) Antibody, clone R1.302 is validated for use in FC, IF for the detection of Nectin-1/PVRL1 (CD111).
    主要应用
    • Flow Cytometry
    应用说明 Immunofluorescence Analysis: A previous lot was used by an independent laboratory in IF (Cocchi, F., et al. (1998). Journal of Virology. 72(12):9992–10002).
    生物信息
    免疫原品种 Human CD111 transfected NIH/3T3 cells
    克隆 R1.302.12
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG1κ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_002846
    Entrez基因汇总 This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq].
    基因符号
    • HveC
    • PVRR
    • PRR1
    • PVRR1
    • CLPED1
    • OFC7
    • HVEC
    • SK-12
    • PRR
    • CD111
    • ED4
    • PVRL1
    • HIgR
    纯化方法 Protein G Purified
    UniProt编号
    • Q15223
    UniProt汇总 FUNCTION: Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4.

    SUBUNIT STRUCTURE: Can form trans-heterodimers with PVRL3/nectin-3 and with PVRL4/nectin-4. Interacts (via C-terminus) with afadin (via PDZ domain); this interaction recruits PVRL1 to cadherin-based adherens junctions. Interacts with integrin alphaV/beta3. Interacts with herpes simplex virus 1 (HHV-1), herpes simplex virus 2 (HHV-2), and pseudorabies virus (PRV) envelope glycoprotein D; functions as an entry receptor for these viruses.

    SUBCELLULAR LOCATION: Isoform Alpha: Cell membrane; Single-pass type I membrane protein.

    Isoform Delta: Cell membrane; Single-pass type I membrane protein.

    Isoform Gamma: Secreted.

    INVOLVEMENT IN DISEASE: Defects in PVRL1 are the cause of ectodermal dysplasia Margarita Island type (EDMI) [MIM:225060]; also known as Zlotogora-Ogur syndrome, cleft lip/palate-ectodermal dysplasia syndrome (CLPED1) or ectodermal dysplasia 4. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDMI is an autosomal recessive syndrome characterized by the association of cleft lip/palate, ectodermal dysplasia (sparse short and dry scalp hair, sparse eyebrows and eyelashes), and partial syndactyly of the fingers and/or toes. Two thirds of the patients do not manifest oral cleft but present with abnormal teeth and nails.

    Defects in PVRL1 are the cause of non-syndromic orofacial cleft type 7 (OFC7) [MIM:225060]. Non-syndromic orofacial cleft is a common birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum.

    SEQUENCE SIMILARITIES: Belongs to the nectin family.

    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

    Contains 1 Ig-like V-type (immunoglobulin-like) domain.

    SEQUENCE CAUTION: The sequence CAA53980.2 differs from that shown. Reason: Erroneous initiation.
    产品使用声明
    质量保证 Evaluated by Flow Cytometry in human TF-1 cells.

    Flow Cytometry Analysis: 0.25 µg of this antibody detected Nectin-1/PVRL1 in human TF-1 cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,MABT61,Anti-Nectin-1/PVRL1 (CD111) Antibody, clone R1.302

上一件merck millipore产品：merck millipore,默克密理博,MAB885-KC,Anti-Papillomavirus, 16L1, late protein, clone Cam Vir-1 (1mg) KC
下一件merck millipore产品：merck millipore,默克密理博,203390,(±)-Blebbistatin - CAS 674289-55-5 - Calbiochem


相关产品

merck millipore,默克密理博,AP501F,Goat Anti-Mouse IgM+IgG+IgA (H+L) Antibody, FITC conjugate, Species Adsorbed merck millipore,默克密理博,AP501F,Goat Anti-Mouse IgM+IgG+IgA (H+L) Antibody, FITC conjugate, Species Adsorb...

merck millipore,默克密理博,06-272,Anti-JAK1 Antibody merck millipore,默克密理博,06-272,Anti-JAK1 Antibody

merck millipore,默克密理博,05-753,Anti-WT1 Antibody, clone 6F-H2 merck millipore,默克密理博,05-753,Anti-WT1 Antibody, clone 6F-H2

merck millipore,默克密理博,539604,PKCη Pseudosubstrate Inhibitor, Myristoylated - Calbiochem merck millipore,默克密理博,539604,PKCη Pseudosubstrate Inhibitor, Myristoylated - Calbiochem

merck millipore,默克密理博,MAB885-KC,Anti-Papillomavirus, 16L1, late protein, clone Cam Vir-1 (1mg) KC merck millipore,默克密理博,MAB885-KC,Anti-Papillomavirus, 16L1, late protein, clone Cam Vir-1 (1mg) KC

merck millipore,默克密理博,203390,(±)-Blebbistatin - CAS 674289-55-5 - Calbiochem merck millipore,默克密理博,203390,(±)-Blebbistatin - CAS 674289-55-5 - Calbiochem

merck millipore,默克密理博,SF-1988,CYLD; Human, Cyanine 5 RNA Detection Probe,SmartFlare merck millipore,默克密理博,SF-1988,CYLD; Human, Cyanine 5 RNA Detection Probe,SmartFlare

merck millipore,默克密理博,AB1284,Anti-Heme Oxygenase 1 Antibody merck millipore,默克密理博,AB1284,Anti-Heme Oxygenase 1 Antibody

merck millipore,默克密理博,609315,Thyroid Hormone Receptor Antagonist, 1-850 - CAS 251310-57-3 - Calbiochem merck millipore,默克密理博,609315,Thyroid Hormone Receptor Antagonist, 1-850 - CAS 251310-57-3 - Calbiochem

merck millipore,默克密理博,SF-1131,miR-30a-5p; Human, Cyanine 5 RNA Detection Probe,SmartFlare merck millipore,默克密理博,SF-1131,miR-30a-5p; Human, Cyanine 5 RNA Detection Probe,SmartFlare


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部