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品种反应性 主要应用 宿主 格式 抗体类型 R, B, M WB, IHC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB1284 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Heme Oxygenase 1 Antibody Alternate Names - HSP32
- HO-1
产品信息 格式 Affinity Purified 控制 - Lung
演示 Affinity Purified immunoglobulin. Liquid in PBS containing 0.01M sodium azide. 应用 应用 This Anti-Heme Oxygenase 1 Antibody is validated for use in IH, WB for the detection of Heme Oxygenase 1. 主要应用 - Western Blotting
- Immunohistochemistry
应用说明 Western Blot: 1:1,000 (using ECL). A single band of ~32 kD is observed. Reactivity can be completely abolished by pre-adsorption of the antibody with the complementary peptide (Catalog Number AG253). Also available are microsomal tissue preparations for control purposes (Rat spleen microsomal preparation, Catalog Number AG257).
Immunohistochemistry: 1:50-1:1,000 on human airway biopsy, human spleen, human kidney and porcine arteries.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 A synthetic peptide with the amino acid sequence H-D-L-S-E-A-L-K-E-A-T-K-E-V-H-C-NH2 corresponding to amino acid residues [12-25] + Cys-NH2 of the human HO-1 protein (Yoshida et al., 1988). 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes Heme oxygenase-1. 品种反应性 RatBovineMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_002133.1
Entrez基因汇总 Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. 基因符号 - bK286B10
- HMOX1
- HO
- OTTHUMP00000028925
- HO1
- HO-1
非反应性品种 - Canine
纯化方法 Immunoaffinity purified UniProt编号 - P09601
UniProt汇总 FUNCTION: SwissProt: P09601 # Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed.
SIZE: 288 amino acids; 32819 Da
SUBCELLULAR LOCATION: Microsome.
SIMILARITY: SwissProt: P09601 ## Belongs to the heme oxygenase family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 50 µg
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