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merck millipore,默克密理博,05-753,Anti-WT1 Antibody, clone 6F-H2
产品名称：Anti-WT1 Antibody, clone 6F-H2
产品型号：05-753
Anti-WT1 Antibody, clone 6F-H2 is a Mouse Monoclonal Antibody for detection of WT1 also known as Wilms' Tumor & has been tested in WB, ICC & IHC.
merck millipore,默克密理博,05-753,Anti-WT1 Antibody, clone 6F-H2
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB, ICC M Purified Monoclonal Antibody 描述 产品目录编号 05-753 品牌系列 Upstate
商名 - Upstate
描述 Anti-WT1 Antibody, clone 6F-H2 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Anti-WT1 Antibody, clone 6F-H2 is a Mouse Monoclonal Antibody for detection of WT1 also known as Wilms' Tumor & has been tested in WB, ICC & IHC. 主要应用 - Immunohistochemistry
- Western Blotting
- Immunocytochemistry
生物信息 免疫原品种 6His-tagged fusion protein corresponding to residues 1-181 of human WT1 (Wilms tumor) 克隆 clone 6F-H2 宿主 Mouse 特异性 WT1 同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_024426
Entrez基因汇总 This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. Multiple transcript variants, resulting from alternative splicing at two coding exons, have been well characterized. There is also evidence for the use of non-AUG (CUG) translation initiation site upstream of, and in-frame with the first AUG, leading to additional isoforms. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. 基因符号 - WIT-2
- WT1
- WAGR
- GUD
- WT33
纯化方法 Protein G purfied UniProt编号 - P19544
UniProt汇总 FUNCTION: SwissProt: P19544 # Potential role in transcriptional regulation. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'.
SIZE: 449 amino acids; 49188 Da
SUBUNIT: Interacts with ZNF224 via the zinc-finger region. Interacts with WTAP and SRY.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Expressed in the kidney and a subset of hematopoietic cells.
DISEASE: SwissProt: P19544 # Defects in WT1 are the cause of Frasier syndrome (FS) [MIM:136680]. FS is characterized by a slowly progressing nephropathy leading to renal failure in adolescence or early adulthood, male pseudohermaphroditism, and no Wilms tumor. As for histological findings of the kidneys, focal glomerular sclerosis is often observed. There is phenotypic overlap with Denys-Drash syndrome. Inheritance is autosomal dominant. & Defects in WT1 are the cause of the genitourinary dysplasia component of WAGR syndrome (GUD) [MIM:137357]. WAGR syndrome is a contiguous gene syndrome characterized by Wilms tumor, aniridia, genitourinary anomalies and mental retardation. These clinical features are due to defects in different genes. & Defects in WT1 are the cause of Wilms tumor 1 (WT1) [MIM:194070]. WT is an embryonal malignancy of the kidney that affects approximately 1 in 10'000 infants and young children. It occurs both in sporadic and hereditary forms. & Defects in WT1 are the cause of Denys-Drash syndrome (DDS) [MIM:194080]. DDS is a typical nephropathy characterized by diffuse mesangial sclerosis, genital abnormalities, and/or Wilms tumor. There is phenotypic overlap with WAGR syndrome and Frasier syndrome. Inheritance is autosomal dominant, but most cases are sporadic. & Defects in WT1 are the cause of isolated diffuse mesangial sclerosis (IDMS) [MIM:256370]. IDMS is an early-onset nephrotic syndrome occurring in the absence of other abnormalities and resulting in renal failure. Inheritance is autosomal recessive. & A chromosomal aberration involving WT1 may be a cause of desmoplastic small round cell tumor (DSRCT). Translocation t(11;22)(p13;q12) with EWSR1.
SIMILARITY: SwissProt: P19544 ## Belongs to the EGR C2H2-type zinc-finger protein family. & Contains 4 C2H2-type zinc fingers.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysates from Jurkat and Raji cells 销售限制 Due to license agreement restrictions, this product cannot be purchased for resale. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
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