merck millipore,默克密理愽
  • merck millipore,默克密理博,ABC118,Anti-phospho Beclin Antibody (Thr119)

  • merck millipore,默克密理博,ABC118,Anti-phospho Beclin Antibody (Thr119)

    产品名称：Anti-phospho Beclin Antibody (Thr119)
    产品型号：ABC118
    Detect Beclin using this rabbit polyclonal antibody, Anti-phospho Beclin Antibody (Thr119) validated for use in western blotting & Peptide Inhibition Assay.

    merck millipore,默克密理博,ABC118,Anti-phospho Beclin Antibody (Thr119)

  • 产品介绍
  • merck millipore,默克密理博,ABC118,Anti-phospho Beclin Antibody (Thr119)

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABC118
    描述 Anti-phospho Beclin Antibody (Thr119)
    Alternate Names
    • Protein GT197
    • Beclin-1
    • Coiled-coil myosin-like BCL2-interacting protein
    背景信息 The Beclin-1 (BECN1) gene encodes a 60 kDa coiled-coil protein that interacts with the prototypic apoptosis inhibitor Bcl-2. Beclin-1 promotes autophagy in autophagy-defective yeast with a targeted disruption of agp6/vps30, and in human MCF7 breast carcinoma cells. The autophagy-promoting activity of Beclin-1 in MCF7 cells is associated with inhibition of MCF7 cellular proliferation, in vitro clonigenicity, tumorigenesis, and has been found to ameliorate the neurodegenerative pathology in α-Synuclein models of Parkinson's and lewy body diseases. Endogenous Beclin-1 protein expression is frequently low in human breast epithelial carcinoma cell lines and tissue, but is expressed ubiquitously at high levels in normal breast epithelia. It has also been shown that Beclin 1 contains a leucine-rich nuclear export signal motif raising the possibility that its autophagy and/or tumor suppressor function may require regulated, CRM1-dependent, nucleocytoplasmic transport.
    产品信息
    格式 Affinity Purified
    控制
    • Human prostate tumor tissue lysate.
    演示 Purified rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Detect Beclin using this rabbit polyclonal antibody, Anti-phospho Beclin Antibody (Thr119) validated for use in western blotting & Peptide Inhibition Assay.
    主要应用
    • Western Blotting
    应用说明 Western Blotting/Peptide Inhibition Analysis: 5 µg/mL from a representative lot detected phospho Beclin (Thr119) in LNCap cell lysate. Peptide inhibition was observed with the addition of phospho peptides, but not with the addition of non-phospho peptides.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to the BH3 domain of human Beclin phosphorylated at Thr119.
    表位 BH3 domain
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes the BH3 domain of Beclin phosphorylated at Thr119.
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human. Predicted to react with Mouse, Rat, Bovine, Chicken, Porcine, Xenopus based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_003757
    基因符号
    • BECN1
    纯化方法 Affinity purified
    UniProt编号
    • Q14457
    产品使用声明
    质量保证 Evaluated by Western Blotting in human prostate tumor tissue lysate.

    Western Blotting Analysis: 5 µg/mL of this antibody detected 10 µg of human prostate tumor tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,ABC118,Anti-phospho Beclin Antibody (Thr119)

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