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merck millipore,默克密理博,12-379,Acetyl-Histone H4 (Lys5, 8, 12, 16) Peptide, biotin conjugate
产品名称：Acetyl-Histone H4 (Lys5, 8, 12, 16) Peptide, biotin conjugate
产品型号：12-379
Acetyl-Histone H4 (Lys5, 8, 12, 16) Peptide, biotin conjugate primarily used in Immunoprecipitation and Affinity Precipitation Assays.
merck millipore,默克密理博,12-379,Acetyl-Histone H4 (Lys5, 8, 12, 16) Peptide, biotin conjugate
- 产品介绍
重要规格表
主要应用 Entrez基因编号 修改 Uni Prot编号 APA, IP NM_003538.3 Acetylation P62805 描述 产品目录编号 12-379 品牌系列 Upstate
商名 - Upstate
描述 Acetyl-Histone H4 (Lys5, 8, 12, 16) Peptide, biotin conjugate 概述 Synthetic peptide, containing amino acids 1-18 of Histone H4 followed by a GSGS linker and biotinylated lysine (SGRGACKGGACKGLGAC-KGGAACKRHGSGSK-biotin). 产品信息 演示 Lyophilized powder 应用 应用 Acetyl-Histone H4 (Lys5, 8, 12, 16) Peptide, biotin conjugate primarily used in Immunoprecipitation and Affinity Precipitation Assays. 主要应用 - Affinity Precipitation Assay
- Immunoprecipitation
生物信息 Entrez基因编号 - NM_003538.3
Entrez基因汇总 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. 基因符号 - H4FN
- H4FA
- H4FH
- HIST1H4H
- H4F2
- H4FM
- H4/A
- H4FK
- H4FG
- HIST2H4
- H4FB
- H4/K
- HIST1H4I
- H4/N
- HIST1H4B
- H4FE
- H4/M
- H4/a
- HIST1H4E
- HIST4H4
- HIST2H4A
- H4FC
- H4FI
- H4/H
- HIST1H4C
- H4/G
- HIST1H4K
- H4FJ
- H4FD
- H4/I
- H4/B
- H4/D
- H4/C
- HIST1H4J
- HIST1H4D
- H4/E
- HIST1H4A
- H4/J
- HIST1H4F
- HIST1H4L
修改 - Acetylation
UniProt编号 - P62805
UniProt汇总 FUNCTION: SwissProt: P62805 # Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
SIZE: 103 amino acids; 11367 Da
SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
SUBCELLULAR LOCATION: Nucleus.
PTM: Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity). & Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.
SIMILARITY: SwissProt: P62805 ## Belongs to the histone H4 family.产品使用声明 质量保证 Routinely evaluated in a kinase assay using MAPKAP Kinase 2, active (Catalog # 14-216 & 14-337) to phosphorylate the substrate peptide. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 50 µg
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