merck millipore,默克密理博,569615,Stem-Cell Factor/c-Kit Inhibitor, ISCK03 - CAS 945526-43-2

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Merck Millipore 默克密理愽

merck millipore,默克密理博,569615,Stem-Cell Factor/c-Kit Inhibitor, ISCK03 - CAS 945526-43-2 - Calbiochem

经验配方	CAS号
C₁₉H₂₁N₃O₂S	945526-43-2

描述
概述	A cell-permeable phenyl-imidazolosulfonamide compound that inhibits c-kit activity (IC50 <<2.5 µM in cell-free kinase assays) and blocks SCF-induced c-kit and Erk phosphorylation (1 µM causes >90% inhibition) without any effect on HGF-induced Erk phosphorylation in 501mel melanoma cells. Oral administration of ISCK03 is shown to induce hair depigmentation in C57BL/6 mice in a dose-dependent and reversible manner. Topical application is likewise demonstrated to decrease UV-induced pigmentation and epidermal melanin level in Brownish guinea pigs in vivo.
产品目录编号	569615
品牌系列	Calbiochem®
同义词	4-t-Butylphenyl-N-(4-imidazol-1-yl-phenyl)sulfonamide, SCF/c-Kit Signaling Inhibitor, ISCK03, c-Kit Inhibitor II

参考
参考	Na, Y.J., et al. 2007. Biochem. Pharmacol. 74, 780.

生物信息
纯度	≥97% by HPLC

理化信息
溶解度	DMSO or EtOH

安全信息
S相	S: 22-24/25-36-45 Do not breathe dust. Avoid contact with skin and eyes. Wear suitable protective clothing. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,569615,Stem-Cell Factor/c-Kit Inhibitor, ISCK03 - CAS 945526-43-2 - Calbiochem

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