merck millipore,默克密理愽
  • merck millipore,默克密理博,MABC555,Anti-Caspase 12 Antibody, clone 14F7

  • merck millipore,默克密理博,MABC555,Anti-Caspase 12 Antibody, clone 14F7

    产品名称：Anti-Caspase 12 Antibody, clone 14F7
    产品型号：MABC555
    Detect Caspase 12 using this rat monoclonal antibody, Anti-Caspase 12 Antibody, clone 14F7 validated for use in western blotting, ICC & IHC.

    merck millipore,默克密理博,MABC555,Anti-Caspase 12 Antibody, clone 14F7

  • 产品介绍
  • merck millipore,默克密理博,MABC555,Anti-Caspase 12 Antibody, clone 14F7

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, M, HIHC, WB, ICCRPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABC555
    描述 Anti-Caspase 12 Antibody, clone 14F7
    Alternate Names
    • CASP-12
    • Caspase-12
    背景信息 Three distinct signaling pathways lead to apoptosis. The death receptor and mitochondrion pathways are the two mains, which involve respectively caspase-8 and caspase-9. The endoplasmic reticulum stress is the third apoptotic pathway and involves caspase-12. Localized to the ER but not to cytoplasm or mitochondria, caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including g-secretase presenilin and b-amyloid precursor protein (APP). Caspase-12 mediates ER stress-induced apoptosis as well as cytotoxicity induced by amyloid-b. Caspase-12 is ubiquitously expressed in mouse tissues.
    产品信息
    格式 Purified
    演示 Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Detect Caspase 12 using this rat monoclonal antibody, Anti-Caspase 12 Antibody, clone 14F7 validated for use in western blotting, ICC & IHC.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    • Immunocytochemistry
    应用说明 Western Blotting Analysis: A representative lot used by an independent laboratory detected Caspase 12 in mouse cerebral tissue lysate and in PC12 cells treated with hapsigargin or A23187. (Nakagawa, T., et al. (2000). Nature. 403(6765):98-103.)
    Immunocytochemistry Analysis: A representative lot used by an independent laboratory detected Caspase 12 in L929 and HeLa cells. (Nakagawa, T., et al. (2000). Nature. 403(6765):98-103.)
    Immunohistochemistry Analysis: A representative lot used by an independent laboratory detected Caspase 12 in mouse kidney tissues. (Nakagawa, T., et al. (2000). Nature. 403(6765):98-103.)
    生物信息
    免疫原品种 His-tagged recombinant protein corresponding to amino acids 95-318 of mouse Caspase 12.
    克隆 14F7
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rat
    同种型 IgG2aκ
    品种反应性 RatMouseHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_033938
    基因符号
    • Casp12
    纯化方法 Protein G purified
    UniProt编号
    • O08736
    产品使用声明
    质量保证 Evaluated by Western Blotting in NIH-3T3 cell lysate.

    Western Blotting Analysis: 1.0 µg/mL of this antibody detected Caspase 12 in 10 µg of NIH-3T3 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABC555,Anti-Caspase 12 Antibody, clone 14F7

上一件merck millipore产品：merck millipore,默克密理博,GF069,Macrophage Inflammatory Protein-3 α Protein, Recombinant human
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