merck millipore,默克密理博,MABE90,Anti-ASF1a Antibody, clone MPH7

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merck millipore,默克密理博,MABE90,Anti-ASF1a Antibody, clone MPH7
产品名称：Anti-ASF1a Antibody, clone MPH7
产品型号：MABE90
Use Anti-ASF1a Antibody, clone MPH7 (Mouse Monoclonal Antibody) validated in IP to detect ASF1a also known as Histone chaperone ASF1A, hAsf1 or Asf1a.

merck millipore,默克密理博,MABE90,Anti-ASF1a Antibody, clone MPH7

产品介绍

merck millipore,默克密理博,MABE90,Anti-ASF1a Antibody, clone MPH7

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	IP	M	Purified	Monoclonal Antibody

描述
产品目录编号	MABE90
描述	Anti-ASF1a Antibody, clone MPH7
Alternate Names	hCIA CIA CCG1-interacting factor A Asf1a hAsf1 Anti-silencing function protein 1 homolog A Histone chaperone ASF1A
背景信息	ASF1a (anti-silencing function 1a) is a histone H3/H4 chaperone and chromatin regulator. This protein facilitates histone placement, removal and exchange during nucleosome assembly/disassembly and is essential for the formation of senescence-associated heterochromatic foci (SAHF). ASF1a interacts with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication independent chromatin assembly.

产品信息
格式	Purified
控制	Jurkat cell lysate
演示	Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	Use Anti-ASF1a Antibody, clone MPH7 (Mouse Monoclonal Antibody) validated in IP to detect ASF1a also known as Histone chaperone ASF1A, hAsf1 or Asf1a.
主要应用	Immunoprecipitation
应用说明	This antibody is not recommended for western blotting.

生物信息
免疫原品种	GST tagged recombinant protein corresponding to human ASF1a.
克隆	MPH7
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
特异性	This antibody recognizes ASF1a, but not ASF1b (Ambagala, A.P., et al. (2009). J Virol. 83(1):200-209.)
同种型	IgG2bκ
品种反应性	Human
Species Reactivity Note	Demonstrated to react with Human.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_054753
Entrez基因汇总	This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair.
基因符号	HSPC146 ASF1A CGI-98
纯化方法	Protein G purified
UniProt编号	Q9Y294
UniProt汇总	FUNCTION: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. SUBUNIT STRUCTURE: Interacts with histone H3 (including both histone H3.1 and H3.3) and histone H4. Interacts with the CHAF1A, CHAF1B and RBBP4 subunits of the CAF-1 complex. Interacts with CABIN1, HAT1, HIRA, NASP, TAF1, TLK1, TLK2 and UBN1. SUBCELLULAR LOCATION: Nucleus.

产品使用声明
质量保证	Evaluated by Immunoprecipitation in Jurkat cell lysate. Immunoprecipitation Analysis: 10 µg of this antibody immunoprecipitated ASF1a from 100 µg of Jurkat cell lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,MABE90,Anti-ASF1a Antibody, clone MPH7

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