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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, M IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MABN221 描述 Anti-NCAM1 Antibody, clone 11G7.1 Alternate Names - CD56
- Neural cell adhesion molecule 1
- N-CAM-1
- NCAM-1
背景信息 The Immunoglobulin superfamily of cell adhesion molecules is related to the immunoglobulin proteins by structure. The family contains over a 100 members, which include ICAM (intercellular adhesion molecule), NCAM (neural cell adhesion molecule) and NgCAM (neural-glial cell adhesion molecule). Both NCAM and NgCAM are calcium independent adhesion molecules. NCAM, the first CAM to be characterized, is expressed on all neurons from very early in development. It binds homophilically to NCAM on adjacent cells and has a variety of functions during neural evelopment. One of these important functions is to hold developing neurites together during neuron outgrowth and formation of neural connections. The adhesive properties of NCAM are modulated during development and plasticity by the presence of the regulated carbohydrate, polysialic acid (PSA). The post-translational addition of alpha-2,8-linked PSA (NCAM-PSA) appears to contribute to synaptic plasticity during learning and memory formation and to the mechanisms of nerve regeneration. 产品信息 格式 Purified 控制 - Rat brain tissue lysate
演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This NCAM1 antibody is validated for use in WB & IHC for the detection of the NCAM1 protein. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Western Blot Analysis: 0.5 µg/mL from a representative lot detected NCAM1 in 10 µg of mouse brain tissue lysate.
Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected NCAM1 in rat hippocampus and rat cerebral cortex tissues.生物信息 免疫原品种 GST-tagged recombinant protein corresponding to the cytoplasmic domain of mouse NCAM1. 表位 cytoplasmic domain 克隆 11G7.1 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody recognizes the cytoplasmic domain of NCAM1. 同种型 IgG1κ 品种反应性 RatMouse Species Reactivity Note Demonstrated to react with Mouse and Rat. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_001074914
基因符号 - Ncam
- Ncam1
纯化方法 Protein G purified UniProt编号 - P13595
产品使用声明 质量保证 Evaluated by Western Blot in rat brain tissue lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected NCAM1 in 10 µg of rat brain tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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