merck millipore,默克密理愽
  • merck millipore,默克密理博,566331,SIRT2 Inhibitor II, AK-1 - CAS 330461-64-8 - Calbiochem

  • merck millipore,默克密理博,566331,SIRT2 Inhibitor II, AK-1 - CAS 330461-64-8 - Calbiochem

    产品名称：SIRT2 Inhibitor II, AK-1 - CAS 330461-64-8 - Calbiochem
    产品型号：566331
    The SIRT2 Inhibitor II, AK-1, also referenced under CAS 330461-64-8, controls the biological activity of SIRT2. This small molecule/inhibitor is primarily used for Cell Structure applications.

    merck millipore,默克密理博,566331,SIRT2 Inhibitor II, AK-1 - CAS 330461-64-8 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,566331,SIRT2 Inhibitor II, AK-1 - CAS 330461-64-8 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₉H₂₁N₃O₅S330461-64-8
    描述
    概述 A cell permeable, benzylsulfonamide that inhibits SIRT2 activity (IC50= 12.5 µM through enzymatic assay) by targeting the SIRT2 nicotinamide binding site, but may also target SIRT1 and SIRT3 (IC50 >40 µM) with much less potency. Western analysis illustrates that treatment with AK-1 (> 25 µM) leads to an increase in acetylated tubulin. AK-1 (1 to 10 µM) is shown to rescue neuronal dysfunction in two in vivo models of Huntington's Disease (HD) in Dropshila and Caenorhabditis elegans. It also demonstrates recovery of neuronal toxicity in a primary model of HD from 1µM to 4 µM similar to that of genetic SIRT2 inhibition, and also correlates with the negative regulation of sterol biosynthesis.
    产品目录编号 566331
    品牌系列 Calbiochem®
    同义词 3-(azepan-1-ylsulfonyl)-N-(3-nitrophenyl)benzamide, SIRT2 Inhibitor II, AK-1
    参考
    参考 Luthi-Carter, R., et al. 2010. Proc. Natl. Acad. Sci. 107, 7927.
    Outeiro, TF., et al. 2007. Science 317, 516.
    产品信息
    CAS号 330461-64-8
    形式 Off-white solid
    Hill配方 C₁₉H₂₁N₃O₅S
    化学配方 C₁₉H₂₁N₃O₅S
    Molar Mass 403.45
    结构配方图像
    生物信息
    纯度 >95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

    merck millipore,默克密理博,566331,SIRT2 Inhibitor II, AK-1 - CAS 330461-64-8 - Calbiochem

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