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merck millipore,默克密理博,492040,Nrf2 Activator - Calbiochem
产品名称：Nrf2 Activator - Calbiochem
产品型号：492040
The Nrf2 Activator modulates the biological activity of Nrf2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
merck millipore,默克密理博,492040,Nrf2 Activator - Calbiochem
- 产品介绍
重要规格表
经验配方 C₁₇H₁₃F₃O₂ 描述 概述 A cell-permeable chalcone that effectively activates NQO1 (NADPH-/quinone oxidoreductase 1) ARE- (antioxidant response element) mediated reporter transcription in human bronchial epithelial Beas-2B cells (7.0-fold of control; 20 µM compound) and induces Nrf2- (Nuclear factor erythroid 2 p45-related factor 2) regulated antioxidants and cytoprotective genes transcription, including GCLM (glutamate-cysteine ligase modifier subunit), NQO1, and HO1 (heme oxygenase-1), both in cultures ([compound] = 10 to 20 µM) in vitro and in mice (50 mg/kg p.o.) in vivo. 产品目录编号 492040 品牌系列 Calbiochem®
同义词 Antioxidant Response Element Activator II, ARE Activator II, (E)-1-(2-Methoxyphenyl)-3-(2-(trifluoromethyl)phenyl)prop-2-en-1-one, Nuclear factor-erythroid 2 p45-related factor 2 Activator, 2-Trifluoromethyl-2ʹ-methoxychalone 参考 参考 Kumar, V., et al. 2011. J. Med. Chem. 54, 4147. 产品信息 形式 Yellow syrup Hill配方 C₁₇H₁₃F₃O₂ 化学配方 C₁₇H₁₃F₃O₂ Molar Mass 306.3 结构配方图像 生物信息 纯度 ≥98% by HPLC 理化信息 溶解度 DMSO or EtOH 储存和货运信息 货运代码 Shipped with Blue Ice or with Dry Ice
毒性 Regulatory Review
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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