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merck millipore,默克密理博,MAB463,Anti-Estrogen Receptor Antibody, clone B10
产品名称：Anti-Estrogen Receptor Antibody, clone B10
产品型号：MAB463
Use Anti-Estrogen Receptor Antibody, clone B10 (Mouse Monoclonal Antibody) validated in ELISA, WB, IHC(P) to detect Estrogen Receptor also known as ER.
merck millipore,默克密理博,MAB463,Anti-Estrogen Receptor Antibody, clone B10
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H WB, ELISA M Ascites Monoclonal Antibody 描述 产品目录编号 MAB463 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Estrogen Receptor Antibody, clone B10 Alternate Names - ER
产品信息 格式 Ascites 演示 Ascites. Liquid, does not contain any preservative. 应用 应用 Use Anti-Estrogen Receptor Antibody, clone B10 (Mouse Monoclonal Antibody) validated in ELISA, WB, IHC(P) to detect Estrogen Receptor also known as ER. 主要应用 - Western Blotting
- ELISA
应用说明 Immunohistochemistry (frozen sections, microwave oven treated paraffin sections) at 1:1,000-1:2,000
Immunocytochemistry (formaldehyde fixation) at 1:1,000-1:2,000
ELISA at 1:1,000-1:2,000
Western blot analysis at 1:1,000-1:2,000
Immunoprecipitation at 1:1-1:10
Gel super shifts at 1:1-1:10
Optimal working dilutions must be determined by the end user.生物信息 表位 a.a. 151-165 克隆 B10 宿主 Mouse 特异性 The peptide used as the immunogen for this product correspond to the amino-acid sequence 151-165 from human ER alpha receptor. By IP, western, gel retardation and ELISA assays clone B10 do not react with other nuclear receptors.
SPECIES REACTIVITIES:
Does not cross react with chicken ER. Other reactivities have not been evaluated. By sequence homology pig ER is 100% identical, rat is 80% conserved.同种型 IgG2a 品种反应性 RatHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_000116.2
Entrez基因汇总 Heparan sulfate proteoglycan is a major component of basement membranes, where the molecule may be involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. This form of HSPG, known as HSPG2 or perlecan, is encoded by a gene that maps to chromosome 1. The gene for the form of HSPG associated with the cell surface of fibroblasts has been mapped to human chromosome 8 (MIM 142460).[supplied by OMIM] 基因符号 - PLC
- HSPG2
- SJA
- perlecan
- SJS
- HSPG
- PRCAN
- Perlecan
- SJS1
UniProt编号 - P03372
UniProt汇总 FUNCTION: SwissProt: P98160 # This protein is an integral component of basement membranes. It is responsible for the fixed negative electrostatic charge and is involved in the charge-selective ultrafiltration properties. It serves as an attachment substrate for cells.
SIZE: 4391 amino acids; 468825 Da
SUBUNIT: Purified perlecan has a strong tendency to aggregate in dimers or stellate structures. It interacts with other basement membrane components such as laminin, prolargin and collagen type IV. Interacts with COL13A1, FGFBP1 and VWA1.
SUBCELLULAR LOCATION: Secreted, extracellular space.
TISSUE SPECIFICITY: Found in the basement membranes.
PTM: N- and O-glycosylated; contains three heparan sulfate chains.
DISEASE: SwissProt: P98160 # Defects in HSPG2 are the cause of Schwartz-Jampel syndrome (SJS1) [MIM:255800]; a rare autosomal recessive disorder characterized by permanent myotonia (prolonged failure of muscle relaxation) and skeletal dysplasia, resulting in reduced stature, kyphoscoliosis, bowing of the diaphyses and irregular epiphyses. & Defects in HSPG2 are the cause of dyssegmental dysplasia Silverman-Handmaker type (DDSH) [MIM:224410]. The dyssegmental dysplasias are rare, autosomal recessive skeletal dysplasias with anisospondyly and micromelia. There are two recognized types: the severe, lethal DDSH and the milder Rolland-Desbuquois form. Individuals with DDSH also have a flat face, micrognathia, cleft palate and reduced joint mobility, and frequently have an encephalocoele. The endochondral growth plate is short, the calcospherites (which are spherical calcium-phosphorus crystals produced by hypertrophic chondrocytes) are unfused, and there is mucoid degeneration of the resting cartilage.
SIMILARITY: SwissProt: P98160 ## Contains 4 EGF-like domains. & Contains 22 Ig-like C2-type (immunoglobulin-like) domains. & Contains 11 laminin EGF-like domains. & Contains 3 laminin G-like domains. & Contains 3 laminin IV type A domains. & Contains 4 LDL-receptor class A domains. & Contains 1 SEA domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots up to 12 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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