merck millipore,默克密理愽
  • merck millipore,默克密理博,553525,RAD51 Inhibitor, B02 - CAS 1290541-46-6 - Calbiochem

  • merck millipore,默克密理博,553525,RAD51 Inhibitor, B02 - CAS 1290541-46-6 - Calbiochem

    产品名称：RAD51 Inhibitor, B02 - CAS 1290541-46-6 - Calbiochem
    产品型号：553525
    The RAD51 Inhibitor, B02 controls the biological activity of RAD51. This small molecule/inhibitor is primarily used for Cell Structure applications.

    merck millipore,默克密理博,553525,RAD51 Inhibitor, B02 - CAS 1290541-46-6 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,553525,RAD51 Inhibitor, B02 - CAS 1290541-46-6 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₂H₁₇N₃O1290541-46-6
    描述
    概述 A cell-permeable pyridinylvinyl-quinazolinone compound that is shown to specifically inhibit human RAD51 (IC50 = 27.4 µM). Does not affect RecA even at much higher concentration (~250 µM). Directly interacts with RAD51 (Kd = 5.6 µM), and disrupts its binding to DNA and nucleoprotein filament formation. Blocks double-strand break-induced homologous recombination and enhances sensitivity of cells to Cisplatin (Cat. No. 232120) and Mitomycin C (Cat. No. 47589), (Cat. No. 475820). Diminishes co-aggregate formation between RAD51-ssDNA filament and dsDNA. RAD51-Stimulatory Compound-1, RS-1 (Cat. No. 553510) is also available.
    产品目录编号 553525
    品牌系列 Calbiochem®
    同义词 (E)-3-Benzyl-2-(2-(pyridin-3-yl)vinyl)quinazolin-4(3H)-one
    参考
    参考 Huang, F., et al. 2012. J. Med. Chem. 55, 3031.
    Huang, F., et al. 2011. ACS Chem. Biol. 6, 628.
    产品信息
    CAS号 1290541-46-6
    形式 Light yellow powder
    Hill配方 C₂₂H₁₇N₃O
    化学配方 C₂₂H₁₇N₃O
    Molar Mass 339.4
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Regulatory Review
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,553525,RAD51 Inhibitor, B02 - CAS 1290541-46-6 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,528110,PIH - CAS 737-86-0 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,09-094,Anti-RFC1 Antibody


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