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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 09-094 品牌系列 Upstate
商名 - Upstate
描述 Anti-RFC1 Antibody Alternate Names - Replication Factor C1, RF-C, MHC binding factor, beta, A1, MGC51786, MHCBFB, PO-GA, RECC1, RFC, RFC140
- RFC
- RECC1
- PO-GA
- MHCBFB
- MGC51786
- A1
- beta
- MHC binding factor
- RF-C
- Replication Factor C1
背景信息 Replication factor C is a DNA-dependent ATPase that is required for eukaryotic DNA replication and repair. The protein acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It also may have a role in telomere stability. 产品信息 格式 Purified 演示 100 μg of rabbit polyclonal IgG in 100μl of 1X PBS with 0.1% sodium azide. 应用 应用 Anti-RFC1 Antibody detects level of RFC1 & has been published & validated for use in WB. 主要应用 - Western Blotting
应用说明 Suggested dilutions:
Western Blot: 1:1000生物信息 免疫原品种 A synthetic peptide corresponding to amino acids 1125-1140 of human RFC1. 宿主 Rabbit 特异性 RFC1 同种型 IgG 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_002913.3
Entrez基因汇总 The protein encoded by this gene is the large subunit of replication factor C, which is a five subunit DNA polymerase accessory protein. Replication factor C is a DNA-dependent ATPase that is required for eukaryotic DNA replication and repair. The protein acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It also may have a role in telomere stability. 基因符号 - RFC
- RFC1
- RECC1
- RFC140
- PO-GA
- A1
- MHCBFB
- MGC51786
纯化方法 Immunoaffinity purified UniProt编号 - P35251
UniProt汇总 FUNCTION: SwissProt: P35251 # Interacts with C-terminus of PCNA. 5' phosphate residue is required for binding of the N-terminal DNA-binding domain to duplex DNA, suggesting a role in recognition of non-primer template DNA structures during replication and/or repair.
SIZE: 1148 amino acids; 128255 Da
SUBUNIT: Heteropentamer of subunits of 140/145, 40, 38, 37, and 36.5 kDa that forms a complex with PCNA in the presence of ATP.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Wide tissue distribution. Undetectable in placental tissue.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: SwissProt: P35251 ## Belongs to the activator 1 140 kDa subunit family. & Contains 1 BRCT domain.产品使用声明 质量保证 Routinely evaluated by immunoblot. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C from date of shipment 包装信息 数量 100 µg
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下一件merck millipore产品：merck millipore,默克密理博,375115,Heparin Cofactor II, Human Plasma
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