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经验配方 CAS号 C₁₄H₁₄N₄O₃ 737-86-0 描述 概述 A cell-permeable, non-toxic tridendate iron (Fe3+) chelator of the aroyl hydrazone class. Even at low concentrations, highly effective in mobilizing Fe3+ from cells and preventing its uptake from transferrin, even at low concentrations. Exhibits similar specificity and binding affinity as Deferoxamine Mesylate (Cat. No. 252750) but has greater access to mitochondrial iron. Also useful for the management of iron overload disease in experimental models. Inhibits the induction of heme containing indoleamine 2,3-dioxygenase activity. 产品目录编号 528110 品牌系列 Calbiochem®
同义词 pyridoxal isonicotinoyl hydrazone, Iron Chelator III 参考 参考 Buss, J.L., et al. 2002. Biochem. Pharmacol. 64, 1689.
Thomas, S.R., et al. 2001. J. Immunol. 166, 6332.
Hermes-Linda, M., et al. 2000. Biochim. Biophys. Acta 1523, 154.
Blaha, K., et al. 1998. Blood 11, 4368.
Richardson, D.R., and Ponka, P. 1998. J. Lab. Clin. Med. 131, 306.
Richardson, D.R.,et al. 1995. Blood 86, 4295.
Richardson, D.R., et al. 1994. J. Lab. Clin. Med. 124, 660.
Ponka, P., et al. 1988. Biochim. Biophys. Acta 967, 122.
Ponka, P., et al. 1984. Biochim. Biophys. Acta 802, 477.
Ponka, P., et al. 1979. FEBS Lett. 97, 317.产品信息 CAS号 737-86-0 形式 Yellow solid Hill配方 C₁₄H₁₄N₄O₃ 化学配方 C₁₄H₁₄N₄O₃ Molar Mass 286.3 结构配方图像 生物信息 纯度 ≥99% by HPLC 理化信息 溶解度 DMSO or slightly acidic medium 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. Acidic stock solutions are stable for up to 2 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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