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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Serum Polyclonal Antibody 描述 产品目录编号 07-1562 Replaces 04-1047 品牌系列 Upstate
商名 - Upstate
描述 Anti-EZH2 Antibody Alternate Names - EC 2.1.1.43<br />SET domain bifurcated 1<br />ERG-associated protein with SET domain<br />ESET<br />Histone H3-K9 methyltransferase 4<br />H3-K9-HMTase 4<br />Lysine N-methyltransferase 1E
- SETDB1
背景信息 Polycomb protein group complexes are responsible for the regulation of hundreds of genes in mammals and insects. These proteins are responsible for the assembly and packaging of chromatin and for the induction of methylation on Histone H3. EZH2 (enhancer of zeste homologue 2), also known as Enx1, is a member of the polycomb group of proteins and is involved in cell cycle regulation. EZH2 represses transcription via trimethylation of histone H3 on Lys27 (H3K27) as indicated by the fact that RNAi-mediated knockdown of EZH2 resulted in a loss of H3K27 trimethylation. The expression of this protein in human tumors is aggressive for hormone refractory prostate cancer. In breast cancer EZH2 expression was increased in malignant tumors and promoted anchorage independent and invasive growth in vitro.. EZH2, also known as ENX-1, is ubiquitously expressed during early embryo genesis, and becomes restricted to the central and peripheral nervous systems and sites of fetal hematopoiesis during later development. In the adult, EZH2 is restricted to the spleen, testis and placenta. EZH2 and BMI-1 genes are co expressed in Reed-Sternberg cells of Hodgkin’s disease. Coexpression of BMI-1 and EZH2 is also associated with cycling cells and degree of malignancy in B-cell non-Hogkin’s lymphoma. EZH2 is involved in the progression of prostate cancer, and has been identified as a marker of aggressive breast cancer. Two transcript variants encoding distinct isoforms have been identified for this gene. 产品信息 格式 Serum 控制 - A431 cell lysate
应用 应用 Use Anti-EZH2 Antibody (Rabbit Polyclonal Antibody) validated in WB to detect EZH2 also known as SET domain bifurcated 1, ERG-associated protein with SET domain. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated, His-tagged fusion protein corresponding to residues 406-746 of human EHZ2 (similar to enhancer of zeste (Drosophila) homolog 2). Based on accession # BC010858. 宿主 Rabbit 特异性 Recognizes EZH2, Mr ~100 kDa 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_152998.1
- NM_004456.3
Entrez基因汇总 This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Two transcript variants encoding distinct isoforms have been identified for this gene. 基因符号 - ENX-1
- EZH2
- MGC9169
纯化方法 Serum UniProt编号 - BC010858
- Q15910
UniProt汇总 FUNCTION: SwissProt: Q15910 # May be involved in the regulation of gene transcription and chromatin structure.
SIZE: 746 amino acids; 85363 Da
SUBUNIT: Binds ATRX via the SET domain (Probable).
SUBCELLULAR LOCATION: Nucleus (Probable).
TISSUE SPECIFICITY: Expressed in many tissues.
SIMILARITY: SwissProt: Q15910 ## Belongs to the EZ family. & Contains 1 SET domain.
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A产品使用声明 质量保证 Routinely evaluated by immunoblot analysis 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
包装信息 数量 100 µL
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