merck millipore,默克密理博,551600,Quercetin, Dihydrate - CAS 6151-25-3

搜索"Merck Millipore 密理愽"产品

Merck Millipore 默克密理愽

当前位置：首页 > >Merck Millipore > 生命科学研究
生命科学研究

merck millipore,默克密理博,551600,Quercetin, Dihydrate - CAS 6151-25-3 - Calbiochem
产品名称：Quercetin, Dihydrate - CAS 6151-25-3 - Calbiochem
产品型号：551600
A cell-permeable and reversible inhibitor of PIM1 kinase (IC₅₀ = 43 nM), PI 3-K (IC₅₀ = 3.8 µM) and phospholipase A2 (IC₅₀ = 2 µM).

merck millipore,默克密理博,551600,Quercetin, Dihydrate - CAS 6151-25-3 - Calbiochem

产品介绍

merck millipore,默克密理博,551600,Quercetin, Dihydrate - CAS 6151-25-3 - Calbiochem

重要规格表

经验配方	CAS号
C₁₅H₁₀O₇ · 2H₂O	6151-25-3

描述
概述	A cell-permeable and reversible inhibitor of PIM1 kinase (IC₅₀ = 43 nM), PI 3-K (IC₅₀ = 3.8 µM) and phospholipase A₂ (IC₅₀ = 2 µM). Also inhibits mitochondrial ATPase, phosphodiesterases, and protein kinase C. Induces apoptosis in K562, Molt-4, Raji, and MCAS tumor cell lines. Reported to activate sirtuins and promote the survival of eukaryotic cells.
产品目录编号	551600
品牌系列	Calbiochem®
同义词	3,3ʹ,4ʹ,5,7-Pentahydroxyflavone

参考
参考	Bullock, A.N., et al. 2005. J. Med. Chem. 48, 7604. Howitz, K.T., et al. 2003. Nature 425, 191. Wei, Y.Q., et al. 1994. Cancer Res. 54, 4952. Shibasaki, F., et al. 1993. Biochem. J. 289, 227. Matter, W.F., et al. 1992. Biochem. Biophys. Res. Comm. 186, 624. Levy, J., et al. 1984. Biochem. Biophys. Res. Commun. 123, 1227. Graziani, Y., et al. 1983. Eur. J. Biochem. 135, 583. Gschwendt, M., et al. 1983. Biochem. Biophys. Res. Commun. 117, 444. Ruckstuhl, M., et al. 1979. Biochem. Pharmacol. 28, 535. Beretz, A., et al. 1978. Experientia 34, 1054.

参考

Bullock, A.N., et al. 2005. J. Med. Chem. 48, 7604.
Howitz, K.T., et al. 2003. Nature 425, 191.
Wei, Y.Q., et al. 1994. Cancer Res. 54, 4952.
Shibasaki, F., et al. 1993. Biochem. J. 289, 227.
Matter, W.F., et al. 1992. Biochem. Biophys. Res. Comm. 186, 624.
Levy, J., et al. 1984. Biochem. Biophys. Res. Commun. 123, 1227.
Graziani, Y., et al. 1983. Eur. J. Biochem. 135, 583.
Gschwendt, M., et al. 1983. Biochem. Biophys. Res. Commun. 117, 444.
Ruckstuhl, M., et al. 1979. Biochem. Pharmacol. 28, 535.
Beretz, A., et al. 1978. Experientia 34, 1054.

产品信息
CAS号	6151-25-3
具有ATP竞争性	N
形式	Yellow solid
Hill配方	C₁₅H₁₀O₇ · 2H₂O
化学配方	C₁₅H₁₀O₇ · 2H₂O
Molar Mass	338.3
可逆	Y
结构配方图像

生物信息
主靶	PI 3-kinase
主靶IC₅₀	43 nM, 3.8 µM, 2 µM against PIM1 kinase, PI 3-K, and phospholipase A2, respectively
纯度	>95% by HPLC

理化信息
细胞可渗透	Y
溶解度	Acetic Acid, Aqueous Alkali, or DMSO

GHS安全信息
RTECS	LK8950000

安全信息
R相	R: 25-40 Toxic if swallowed. Limited evidence of a carcinogenic effect.
S相	S: 36/37/39-45 Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Toxic & Carcinogenic / Teratogenic
有害材料注意事项：	Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存	+15°C to +30°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.