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品种反应性 主要应用 宿主 格式 抗体类型 H WB M Purified Monoclonal Antibody 描述 产品目录编号 05-1244 描述 Anti-O-GlcNAc Antibody, clone 18B10.C7(3) Alternate Names - uridinediphospho-N-acetylglucosamine:polypeptide<br />beta-N-acetylglucosaminyl transferase
- O-GlcNAc transferase p110 subunit
- O-GlcNAc transferase subunit p110
- O-linked GlcNAc transferase
- O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
- O-linked N-acetylglucosamine transferase 110 kDa subunit
背景信息 O-linked N-acetylglucosamine (O-GlcNAc), is a member of the O-GlcNAc transferase family. O-GlcNAc is a posttranslational modification characterized by the attachment of N-acetylglucosamine to specific serine/threonine hydroxyl groups. It plays an important role in nutrient sensing, gene expression, and protein degradation. O-GlcNAc is widely expressed in the pancreas and is present in smaller amounts in skeletal muscle, heart, brain and placenta. 产品信息 格式 Purified 控制 - HEK293 cell lysate
演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 Anti-O-GlcNAc Antibody, clone 18B10.C7(3) is an antibody against O-GlcNAc for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 SANM-conjugated linear peptide corresponding to human O-GluNAc. 表位 N/A 克隆 18B10.C7 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody recognizes O-GluNAc. 同种型 IgG1κ 品种反应性 Human Species Reactivity Note Proven to react with human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_858058.1
Entrez基因汇总 O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains nine tetratricopeptide repeats and a putative bipartite nuclear localization signal. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq] 基因符号 - O-GLCNAC
- OGT
- HRNT1
纯化方法 Protein G purfied UniProt编号 - O15294
UniProt汇总 FUNCITON: Addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine. Mediates the O-glycosylation of MLL5.
CATALYTIC ACTIVITY: UDP-N-acetyl-D-glucosamine + peptide = UDP + N-acetyl-beta-D-glucosaminyl-peptide.
Pathway Protein modification; protein glycosylation.
SUBUNIT STRUCTURE: Heterotrimer of two 110 kDa and one 70 kDa subunits. It is not known if the 70 kDa subunit is encoded by a separate gene or is the product of either of a proteolytic degradation or an alternative initiation of the 110 kDa subunit By similarity. Component of the MLL5-L complex, at least composed of MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with HCFC1.
SUBCELLULAR LOCATION: Cytoplasm Potential. Nucleus Potential.
TISSUE SPECIFICTY: Highly expressed in pancreas and to a lesser extent in skeletal muscle, heart, brain and placenta. Present in trace amounts in lung and liver.
SEQUENCE SIMILARITIES: Belongs to the O-GlcNAc transferase family.
Contains 13 TPR repeats.产品使用声明 质量保证 Evaluated by Western Blot in O-GlcNAc transferease transfected HEK293 cell lysate and O-GlcNAcase transfected transfected HEK293 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected O-GlcNAc on 10 µg O-GlcNAc transferease transfected HEK293 cell lysate and O-GlcNAcase transfected transfected HEK293 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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