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品种反应性 主要应用 宿主 格式 抗体类型 Eq, H, M, R, B WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 09-478 描述 Anti-phospho-LKB1 (Ser307) Antibody Alternate Names - serine/threonine protein kinase 11
- serine/threonine kinase 11 (Peutz-Jeghers syndrome)
- serine/threonine kinase 11
- polarization-related protein LKB1
- Serine/threonine-protein kinase LKB1
- Renal carcinoma antigen NY-REN-19
背景信息 LKB1 is a serine-threonine protein kinase and member of the calcium calmodulin family. LKB1 acts as a tumor suppressor and plays an important role in the regulation of many cellular processes. It is expressed in all tissues including pancreatic, liver, testicular, cardiac, and skeletal muscle tissue. Mutations in LKB1 result from unregulated cell growth and tumor formation that are associated with Peutz-Jehgers syndrome. 产品信息 格式 Affinity Purified 控制 - Modified and non-modified peptides of phosphorylated and non-phosphorlyated LKB1 protein
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 Anti-phospho-LKB1 (Ser307) Antibody is an antibody against phospho-LKB1 (Ser307) for use in WB, DB. 主要应用 - Western Blotting
应用说明 Western Blot Analysis: A previous lot was used by an independent laboratory in WB. (Xie, Z., et al. (2009). Molecular and Cellular Biology. 29(13):3582-3596.) 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to amino acids including and surrounding phosphorylated Ser307 of human LKB1. 表位 Phosphorylated Ser307 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes LKB1 when phosphorylated at Ser307. 品种反应性 HorseHumanMouseRatBovine Species Reactivity Note Demonstrated to react with human. Predicted to react with mouse, rat, bovine, and equine based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_000446
Entrez基因汇总 This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq]. 基因符号 - PJS
- STK11
- LKB1
修改 - Phosphorylation
纯化方法 Affinity Purfied UniProt编号 - Q15831
UniProt汇总 FUNCTION: Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
COFACTOR: Magnesium or Manganese.
ENZYME REGULATION: Activated by binding of a complex consisting of CAB39 and STRAD or CAB39 and ALS2CR2.
SUBUNIT STRUCTURE: Found in a ternary complex composed of SMAD4, STK11 and STK11IP. Interacts with SMAD4 and STK11IP.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Relocates to the cytoplasm when bound to CAB39 and STRAD or CAB39 and ALS2CR2.
TISSUE SPECIFICITY: Ubiquitously expressed. Strongest expression in testis and fetal liver.
PTM: Phosphorylated by a cAMP-dependent protein kinase By similarity.
INVOLVEMENT IN DISEASE: Defects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) [MIM:175200]. PJS is a rare hereditary disease in which there is predisposition to benign and malignant tumors of many organ systems. PJS is an autosomal dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer.
Defects in STK11 have been associated with testicular tumors [MIM:273300]. It includes germ cell tumor (GCT) or testicular germ cell tumor (TGCT).
SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.
Contains 1 protein kinase domain.产品使用声明 质量保证 Evaluated by Dot Blot in modified and non-modified peptides of phosphorylated and non-phosphorlyated LKB1 protein.
Dot Blot Analysis: 1 µg/mL of this antibody detected LKB1 in modified and non-modified peptides of phosphorylated and non-phosphorlyated LKB1 protein.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 200 µL
上一件merck millipore产品：merck millipore,默克密理博,SF-2355,SSX1; Human, Cyanine 3 RNA Detection Probe,SmartFlare
下一件merck millipore产品：merck millipore,默克密理博,04-1098,Anti-phospho-Jak2 (Tyr1007/Tyr1008) Antibody, clone E132, rabbit monoclonal
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