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merck millipore,默克密理博,AB1926,Anti-Integrin β5 Antibody, CT/cytosolic
产品名称：Anti-Integrin β5 Antibody, CT/cytosolic
产品型号：AB1926
Detect Integrin β5 using this Anti-Integrin β5 Antibody, C-terminus/cytosolic validated for use in ELISA, IF, IH(P), IP, RIA & WB.
merck millipore,默克密理博,AB1926,Anti-Integrin β5 Antibody, CT/cytosolic
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, Ht, M WB, ELISA Rb Serum Polyclonal Antibody 描述 产品目录编号 AB1926 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Integrin β5 Antibody, CT/cytosolic 背景信息 The integrin family of cell adhesion receptors consists of at least 16 membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence, known to be present in the extracellular matrix components fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor (Cheresh, 1991). The involvement of integrins in vascular proliferation, adhesion, and wound repair has been well documented.
The beta5 subunit associates with alphaV forming a receptor for vitronectin. This complex is expressed in a wide range of cell types including fibroblast and keratinocytes. It is also expressed at high levels in several tumors including lung, pancreatic and mammary carcinomas. It is not expressed in lymphblastoid cells.产品信息 格式 Serum 控制 - Skin (Basement Membrane)
演示 UnPurified whole rabbit Serum containing 0.05% sodium azide as a preservative. 应用 应用 Detect Integrin β5 using this Anti-Integrin β5 Antibody, C-terminus/cytosolic validated for use in ELISA, IF, IH(P), IP, RIA & WB. 主要应用 - Western Blotting
- ELISA
应用说明 ELISA/RIA
Immunoprecipitation: 5μL of antibody is sufficient to precipitate alphaVbeta5 from
2.5x10E6 cells.
Western blot: non-reduced conditions; do not use milk in the dilution buffer.
Immunofluorescence: 1:100.
Immunohistochemistry (Acetone Fixed) 1:40-1:80
Immunohistochemistry (Paraffin Embedded) 1:200 (ABC)
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Synthetic peptide derived from the COOH terminal sequence (cytoplasmic domain) of the human integrin beta 5 subunit (KTFNKFNKSYNGTVD). Note : a lysine (K) residue was added to the N-terminal of the peptide to facilitate coupling to the carrier protein. 表位 C-terminus/cytosolic 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes Integrin beta5. Specificity determined by immunoprecipitation from detergent extract of 35S methionine labeled cells. No cross-reactivity to beta1 or beta3. 品种反应性 RatHumanHamsterMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_002213.3
基因符号 - FLJ26658
- ITGB5
纯化方法 Unpurified UniProt编号 - P18084
UniProt汇总 FUNCTION: SwissProt: P18084 # Integrin alpha-V/beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.
SIZE: 799 amino acids; 88054 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-5 associates with alpha-V.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: SwissProt: P18084 ## Belongs to the integrin beta chain family. & Contains 1 PSI domain. & Contains 1 VWFA domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 100 µL
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