merck millipore,默克密理愽
  • merck millipore,默克密理博,14-128,GRB2 Protein, agarose conjugate, 100 µg

  • merck millipore,默克密理博,14-128,GRB2 Protein, agarose conjugate, 100 µg

    产品名称：GRB2 Protein, agarose conjugate, 100 µg
    产品型号：14-128
    Recombinant GST-GRB2 non-covalently bound to glutathione-agarose. For use in Immunoprecipitation & Western Blotting.

    merck millipore,默克密理博,14-128,GRB2 Protein, agarose conjugate, 100 µg

  • 产品介绍
  • merck millipore,默克密理博,14-128,GRB2 Protein, agarose conjugate, 100 µg

    描述
    产品目录编号 14-128
    品牌系列 Upstate
    商名
    • Upstate
    描述 GRB2 Protein, agarose conjugate, 100 µg
    概述 Recombinant GST-GRB2 non-covalently bound to glutathione-agarose.
    应用
    应用 Recombinant GST-GRB2 non-covalently bound to glutathione-agarose. For use in Immunoprecipitation & Western Blotting.
    主要应用
    • Western Blotting
    生物信息
    来源 expressed in E. coli
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_203506.1
    • NM_002086.3
    Entrez基因汇总 The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
    基因符号
    • Grb3-3
    • GRB2
    • ASH
    • MST084
    • EGFRBP-GRB2
    • MSTP084
    • HT027
    UniProt编号
    • P62993
    UniProt汇总 FUNCTION: SwissProt: P62993 # Isoform GRB3-3 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform GRB3-3 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
    SIZE: 217 amino acids; 25206 Da
    SUBUNIT: Associates with activated Tyr-phosphorylated EGF receptors and PDGF receptors via its SH2 domain. Also associates to other cellular Tyr-phosphorylated proteins such as SIT1, IRS1, SHC and LNK; probably via the concerted action of both its SH2 and SH3 domains. It also seems to interact with RAS in the signaling pathway leading to DNA synthesis. Binds to and translocates the guanine nucleotide exchange factors SOS. Interacts with phosphorylated TOM1L1 and MET. Interacts with the phosphorylated C-terminus of SH2B2. Interacts with phosphorylated SIT1, LAX1, LAT, LAT2 and LIME1 upon TCR and/or BCR activation. Interacts with PTPNS1, REPS2 and the syntrophin SNTA1. Interacts with REPS1 and PIK3C2B via its SH3 domains (By similarity). Interacts with HCV NS5A via its SH3 domains. Interacts with CBL and CBLB. Interacts with SHB, INPP5D/SHIP1, SKAP1 and SKAP2.
    DOMAIN: SwissProt: P62993 The SH3 domains mediate interaction with SHB.
    SIMILARITY: Belongs to the GRB2/sem-5/DRK family. & Contains 1 SH2 domain. & Contains 2 SH3 domains.
    产品使用声明
    质量保证 routinely evaluated by immunoblot analysis
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -20 C
    包装信息
    数量 100 µg

    merck millipore,默克密理博,14-128,GRB2 Protein, agarose conjugate, 100 µg

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