merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB88917,Anti-Vitronectin Antibody, clone 8E6(LJ8)

  • merck millipore,默克密理博,MAB88917,Anti-Vitronectin Antibody, clone 8E6(LJ8)

    产品名称：Anti-Vitronectin Antibody, clone 8E6(LJ8)
    产品型号：MAB88917
    Anti-Vitronectin Antibody, clone 8E6(LJ8) detects level of Vitronectin & has been published & validated for use in ELISA, WB, IH.

    merck millipore,默克密理博,MAB88917,Anti-Vitronectin Antibody, clone 8E6(LJ8)

  • 产品介绍
  • merck millipore,默克密理博,MAB88917,Anti-Vitronectin Antibody, clone 8E6(LJ8)

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHC, ELISA, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB88917
    Replaces 04-1108
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Vitronectin Antibody, clone 8E6(LJ8)
    Alternate Names
    • S-protein
    • Serum spreading factor
    产品信息
    格式 Purified
    演示 Purified immunoglobulin. Liquid. Buffer = 0.02M Phosphate buffer, 0.25M NaCl, pH 7.6 with 0.1% sodium azide.
    应用
    应用 Anti-Vitronectin Antibody, clone 8E6(LJ8) detects level of Vitronectin & has been published & validated for use in ELISA, WB, IH.
    主要应用
    • Immunohistochemistry
    • ELISA
    • Western Blotting
    应用说明 Western blot: 5-20 μg/mL Stains cell-binding vitronectin.

    Immunocytochemistry: 5-20 μg/mL

    ELISA: 5-20 μg/mL

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Purified human vitronectin from plasma.
    克隆 8E6(LJ8)
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 The antibody reacts with human vitronectin, it does not react with human fibronectin (Hayman et al., 1983).
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_000638.3
    Entrez基因汇总 The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond.
    基因符号
    • V75
    • VTN
    • S-protein
    • epibolin
    • VNT
    • VN
    UniProt编号
    • P04004
    UniProt汇总 FUNCTION: SwissProt: P04004 # Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.
    SIZE: 478 amino acids; 54306 Da
    SUBUNIT: Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa and 10 kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1 and insulin.
    SUBCELLULAR LOCATION: Secreted, extracellular space.
    TISSUE SPECIFICITY: Plasma.
    DOMAIN: SwissProt: P04004 The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin.
    PTM: Sulfated on 2 tyrosine residues. & N- and O-glycosylated (By similarity). & Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading. & It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.SIMILARITY: Contains 4 hemopexin-like domains. & Contains 1 SMB (somatomedin-B) domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at 2-8°C in undiluted aliquots for up to 12 months.Avoid repeat freeze/thaw cycles.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB88917,Anti-Vitronectin Antibody, clone 8E6(LJ8)

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