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品种反应性 主要应用 宿主 格式 抗体类型 M WB Rb Serum Polyclonal Antibody 描述 产品目录编号 AB15334 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Nab2 Antibody Alternate Names - NGFI-A-binding protein-2, EGR-1-binding protein 2
- NGFI-A-binding protein-2
产品信息 格式 Serum 演示 Rabbit serum. Liquid. 应用 应用 Anti-Nab2 Antibody detects level of Nab2 & has been published & validated for use in WB. 主要应用 - Western Blotting
应用说明 Western blot: 1:1,000-1:5,000 on extracts from mouse brain lysate.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide 宿主 Rabbit 特异性 Nab2 (NGFI-A-binding protein-2, EGR-1-binding protein 2). By Western blot the antibody recognizes a band at ~57 kDa in mouse brain lysate. 品种反应性 Mouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_005967.3
Entrez基因汇总 This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. 基因符号 - MADER
- NAB2
- MGC75085
纯化方法 Serum UniProt编号 - Q15742
UniProt汇总 FUNCTION: SwissProt: Q15742 # Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity).
SIZE: 525 amino acids; 56594 Da
SUBUNIT: Homomultimers may associate with EGR1 bound to DNA (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity). Note=Isoform 2 is not localized to the nucleus (By similarity).
TISSUE SPECIFICITY: Widely expressed at low levels. Highly expressed in melanoma cell lines.
DOMAIN:SwissProt: Q15742 The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization. & The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression.
SIMILARITY: Belongs to the NAB family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
上一件merck millipore产品：merck millipore,默克密理博,219537,D-erythro-Sphingosine, Dihydro-, N-Acetyl- - CAS 13031-64-6 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,MABC164,Anti-Arl1 Antibody, clone 11A12.1
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