merck millipore,默克密理愽
  • merck millipore,默克密理博,14-845,PIP5K1γ Protein, active, 10 µg

  • merck millipore,默克密理博,14-845,PIP5K1γ Protein, active, 10 µg

    产品名称：PIP5K1γ Protein, active, 10 µg
    产品型号：14-845
    Active, N-terminal 6His-tagged, recombinant human PIP5K1γ, full length. For use in Kinase Assays.

    merck millipore,默克密理博,14-845,PIP5K1γ Protein, active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,14-845,PIP5K1γ Protein, active, 10 µg

    描述
    产品目录编号 14-845
    品牌系列 Upstate
    商名
    • Upstate
    描述 PIP5K1γ Protein, active, 10 µg
    概述 N-terminal 6His-tagged, recombinant human PIP5K1γ, full length.
    产品信息
    演示 10µg of enzyme in 50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 0.2mM PMSF, 1mM benzamidine, 0.1% 2-mercaptoethanol. Frozen solution.
    应用
    应用 Active, N-terminal 6His-tagged, recombinant human PIP5K1γ, full length. For use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Expressed by baculovirus in Sf21 insect cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_012398
    Entrez基因汇总 This gene encodes a member of the type I phosphatidylinositol-4-phosphate 5-kinase family of enzymes. A similar protein in mice is found in synapses and focal adhesion plaques, and binds the FERM domain of talin through its C-terminus.
    基因符号
    • KIAA0589
    • PIP5K1C
    蛋白靶 PIP5K1γ
    纯化方法 Immobilized metal affinity chromatography (IMAC)
    靶子系列 PIPK
    UniProt编号
    • O60331
    UniProt汇总 FUNCTION: Plays a role in membrane ruffling and assembly of clathrin-coated pits at the synapse. Mediates RAC1-dependent reorganization of actin filaments. Participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate. CATALYTIC ACTIVITY: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
    Enzyme regulation: Activated by interaction with TLN2.
    SUBUNIT STRUCTURE: Interacts with TLN1 and CSK. Interacts with TLN2 and ARF6. Interacts with AP2B1. Interacts with AP2M1; phosphorylation of PIP5K1C by CSK disrupts the interaction; clathrin competes with PIP5K1C.
    SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note: Cytoplasmic, associated with the plasma membrane. Detected in focal adhesion plaques, membrane ruffles and plasma membrane invaginations.
    INVOLVEMENT IN DISEASE: Defects in PIP5K1C are the cause of lethal congenital contracture syndrome type 3 (LCCS3) [MIM:611369]; also known as multiple contractural syndrome Israeli Bedouin type B. LCCS is an autosomal recessive disorder characterized by early fetal hydrops and akinesia, the Pena-Shokeir phenotype, specific neuropathology with degeneration of anterior horn neurons and extreme skeletal muscle atrophy. LCCS3 patients present at birth with severe multiple joint contractures with severe muscle wasting and atrophy, mainly in the legs. LCCS3 can be distinguished from the original LCCS by the absence of hydrops, fractures, and multiple pterygia.
    SEQUENCE SIMILARITIES: Contains 1 PIPK domain.
    产品使用声明
    质量保证 Routinely evaluated in the PIProfiler.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 10 µg
    包装 Also available in 250μg size as catalog # 14-845M - Call for pricing and availability.

    merck millipore,默克密理博,14-845,PIP5K1γ Protein, active, 10 µg

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下一件merck millipore产品：merck millipore,默克密理博,219537,D-erythro-Sphingosine, Dihydro-, N-Acetyl- - CAS 13031-64-6 - Calbiochem


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