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merck millipore,默克密理博,539109,PAR-2 Agonist I - Calbiochem
产品名称：PAR-2 Agonist I - Calbiochem
产品型号：539109
The PAR-2 Agonist I controls the biological activity of PAR-2. This small molecule/inhibitor is primarily used for Activators/Inducers applications.
merck millipore,默克密理博,539109,PAR-2 Agonist I - Calbiochem
- 产品介绍
重要规格表
经验配方 C₃₁H₅₃N₉O₇ 描述 概述 The native PAR-2-specific agonist, SLIGRL-NH2, is modified with an N-terminal furoyl group to increase its potency and resistance to metabolic degradation. Shown to activate [Ca2+]i mobilization in PAR-2-expressing cells (EC50 = 253 nM using HCT-15 cells) in vitro and induce PAR-2 mediated salivation (ED50 = 30 nmol/kg, i.v.) in vivo, while exhibiting no effect on PAR-2-/- mice. Reactive towards human, rat, and murine PAR-2. 产品目录编号 539109 品牌系列 Calbiochem®
同义词 Proteinase Activated Receptor-2 Agonist I, 2f-LIGRL-amide 参考 参考 Kawabata, A., et al. 2004. J. Pharmacol. Exp. Ther. 309, 108.
Kawabata, A., et al. 2004. J. Pharmacol. Exp. Ther. 309, 1098.
Ferrell, W.R., et al. 2003. J. Clin. Invest. 111, 35.产品信息 具有ATP竞争性 N 形式 White lyophilized solid 配方 Supplied as a trifluoroacetate salt. Hill配方 C₃₁H₅₃N₉O₇ 化学配方 C₃₁H₅₃N₉O₇ Molar Mass 663.8 吸湿 Hygroscopic
肽序列 2-Furoyl-Leu-Ile-Gly-Arg-Leu-NH₂ 可逆 N 生物信息 主靶 PAR-2 主靶IC50 EC50 = 253 nM as PAR-2-specific agonist using HCT-15 cells 纯度 ≥95% by HPLC 理化信息 细胞可渗透 N 溶解度 DMSO 肽序列 2-Furoyl-Leu-Ile-Gly-Arg-Leu-NH₂ 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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