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merck millipore,默克密理博,528117,PI 3-K inhibitor IX, PIK-90 - CAS 677338-12-4 - Calbiochem
产品名称：PI 3-K inhibitor IX, PIK-90 - CAS 677338-12-4 - Calbiochem
产品型号：528117
The PI 3-K inhibitor IX, PIK-90, also referenced under CAS 677338-12-4, controls the biological activity of PI 3-K. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylat More>>
merck millipore,默克密理博,528117,PI 3-K inhibitor IX, PIK-90 - CAS 677338-12-4 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₈H₁₇N₅O₃ 677338-12-4 描述 概述 A cell-permeable imidazoquinazoline compound that acts as a potent, reversible, and ATP-competitive inhibitor against all three classes of PI 3-K kinases (IC50 = 11, 18, 47, 58, 64, 350, and 830 nM against p110α, p110γ, PI 3-KC2α, p110δ, PI 3-KC2β, p110β, and hsVPS34, respectively), as well as several PIKKs (IC50 = 13, 610, and 1050 nM against DNA-PK, ATM, and mTORC1, respectively) and PI 4-KIIIα (IC50 = 830 nM), while exhibiting much reduced potency against PI 4-KIIIβ and ATR (IC50 = 3.1 and 15 µM, respectively) and little or no activity toward PI 4-KIIα, PIPKs (IC50 >100 µM), and a panel of 36 commonly studied protein kinases (<15% inhibition at 10 µM). Effectively suppreses insulin-stimulated phosphorylations of Akt and rpS6 in 3T3-L1 adipocytes and L6 myotubes in a dose-dependent manner in vitro (by >90% at 2.5 µM) and completely prevents insulin-induced blood glucose decline in mice in vivo (10 mg/ml, i.p.). 产品目录编号 528117 品牌系列 Calbiochem®
同义词 N-(2,3-Dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide, mTOR Inhibitor VI 参考 参考 Fan, Q.W., et al. 2007. Cancer Res. 67, 7960.
Fan, Q.W., et al. 2006. Cancer Cell 9, 341.
Knight, Z.A., et al. 2006. Cell 125, 733.产品信息 CAS号 677338-12-4 形式 Pale yellow solid Hill配方 C₁₈H₁₇N₅O₃ 化学配方 C₁₈H₁₇N₅O₃ Molar Mass 351.4 结构配方图像 生物信息 纯度 ≥98% by HPLC 理化信息 溶解度 DMSO 安全信息 S相 S: 22-24/25
Do not breathe dust.
Avoid contact with skin and eyes.储存和货运信息 货运代码 Blue Ice Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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下一件merck millipore产品：merck millipore,默克密理博,33-037,PI 3-Kinase HTRF™ Assay; 50,000 wells
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