merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB3369,Anti-MMP-3 Antibody, clone SL-1 IID4

  • merck millipore,默克密理博,MAB3369,Anti-MMP-3 Antibody, clone SL-1 IID4

    产品名称：Anti-MMP-3 Antibody, clone SL-1 IID4
    产品型号：MAB3369
    Anti-MMP-3 Antibody, clone SL-1 IID4 is an antibody against MMP-3 for use in ELISA, IP, WB, IH(P).

    merck millipore,默克密理博,MAB3369,Anti-MMP-3 Antibody, clone SL-1 IID4

  • 产品介绍
  • merck millipore,默克密理博,MAB3369,Anti-MMP-3 Antibody, clone SL-1 IID4

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWB, ELISAMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB3369
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-MMP-3 Antibody, clone SL-1 IID4
    Alternate Names
    • Proteoglycanase
    • Stromelysin-1
    • Transin
    背景信息 MMPs are frequently expressed in malignant neoplastic cells and play crucial roles in tumor invasion and metastasis. Tissue inhibitors of matrix metalloproteinases (TIMPs) control the activitiy of MMPS. The tissue distribution of three major MMPs has been defined in human mammary pathology: 1) collagenase (MMP-1) which degrades fibrillar interstitial collagens; 2) a 72-k/Da gelatinase (MMP-2) which mainly degrades type IV collagen and denatured collagens; and 3) stromelysin (MMP-3) which has a wider range of action, degrading several matrix components including the core proteins of proteoglycans, laminin and non-helical regions of collagens.
    产品信息
    格式 Purified
    控制
    • POSTIVE CONTROL:

      Human endometrium cells, placenta, bladder, breast, ovarian carcinomas.
    演示 Purified from ascites fluid by Protein A chromatography. 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.
    应用
    应用 Anti-MMP-3 Antibody, clone SL-1 IID4 is an antibody against MMP-3 for use in ELISA, IP, WB, IH(P).
    主要应用
    • Western Blotting
    • ELISA
    应用说明 Immunofluorescence

    Immunoprecipitation (Use Protein A): 2μg/ml protein lysate.

    Western blotting: 0.5-1.0 μg/ml for 2hrs at RT

    Immunohistology (frozen & formalin-fixed): 10-20 μg/ml for 60 minute at room temperature. No special pretreatment is required for staining of formalin-fixed, paraffin-embedded tissue sections.

    Optimal working dilutions and protocols must be determined by end user.
    生物信息
    免疫原品种 APMA (4-Aminophenylmercuric acetate) activated Human stromelysin-1
    克隆 SL-1 IID4
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 MAB3369 recognizes one doublet of 54kDa/59kDa and another doublet of 44kDa/49kDa, which are identified as unglycosylated and glycosylated species of pro (latent) and active forms of matrix metalloproteinase-3 (MMP-3; also known as Stromelysin-1 of Transin). MAB3369 shows no cross-reaction with the pro and active forms of other MMPs.

    CELLULAR LOCALIZATION:

    Cytoplasmic
    同种型 IgG2b
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_002422.3
    Entrez基因汇总 Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
    基因符号
    • EC 3.4.24.17
    • MMP3
    • STR1
    • Transin-1
    • STMY
    • MGC126102
    • STMY1
    • SL-1
    • MGC126103
    • MGC126104
    • transin-1
    • proteoglycanase
    • MMP-3
    • progelatinase
    UniProt编号
    • P08254
    UniProt汇总 FUNCTION: SwissProt: P08254 # Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
    COFACTOR: Binds 4 calcium ions per subunit. & Binds 2 zinc ions per subunit.
    SIZE: 477 amino acids; 53977 Da
    DOMAIN: SwissProt: P08254 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    SIMILARITY: Belongs to the peptidase M10A family. & Contains 4 hemopexin-like domains.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Antibody with sodium azide is stable for 12 months when stored at 2-8°C.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB3369,Anti-MMP-3 Antibody, clone SL-1 IID4

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