merck millipore,默克密理愽
  • merck millipore,默克密理博,138000,D-Amino Acid Oxidase Inhibitor - CAS 39793-31-2 - Calbiochem

  • merck millipore,默克密理博,138000,D-Amino Acid Oxidase Inhibitor - CAS 39793-31-2 - Calbiochem

    产品名称：D-Amino Acid Oxidase Inhibitor - CAS 39793-31-2 - Calbiochem
    产品型号：138000
    The D-Amino Acid Oxidase Inhibitor, also referenced under CAS 39793-31-2, controls the biological activity of D-Amino Acid Oxidase.

    merck millipore,默克密理博,138000,D-Amino Acid Oxidase Inhibitor - CAS 39793-31-2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,138000,D-Amino Acid Oxidase Inhibitor - CAS 39793-31-2 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₇H₅NO₂S39793-31-2
    描述
    概述 A cell-permeable thienopyrrole compound that potently inhibits the cellular activity of transfected D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) in CHO cells (IC50 against human and rat DAO = 145 and 114 nM, respectively), while exhibiting no activity towards D-aspartate oxidase (DDO; IC50 >5 µM), P450 enzymes CYP3A4/2D6/3C9 (IC50 >10 µM), and a panel of over 150 other enzymes, receptors, and ion channels. Although in vivo treatment of Compound 8 (200 mg/kg, i.p.) is shown to effectively inhibit DAO activity in rat brain and kidney (by 96% and 80%, respectively), the resulting D-serine concentration increase in the periphery and central nervous system appears to be far from sufficient to produce adequate antipsychotic and cognitive enhancing effects.
    产品目录编号 138000
    品牌系列 Calbiochem®
    同义词 4H-Thieno[3,2-b]pyrrole-5-carboxylic acid, D-AAO Inhibitor, Compound 8
    参考
    参考 Smith, S.M., et al. 2009. J. Pharmacol. Exp. Ther. 328, 921.
    Sparey, T., et al. 2008. Bioorg. Med. Chem. Lett. 18, 3386.
    产品信息
    CAS号 39793-31-2
    形式 Beige solid
    Hill配方 C₇H₅NO₂S
    化学配方 C₇H₅NO₂S
    Molar Mass 167.2
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO or 5% NaOH
    安全信息
    R相 R: 22-36/37/38

    Harmful if swallowed.
    Irritating to eyes, respiratory system and skin.
    S相 S: 26-36/37/39

    In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    Wear suitable protective clothing, gloves and eye/face protection.
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Harmful
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Unstable in solution; reconstitute just prior to use.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,138000,D-Amino Acid Oxidase Inhibitor - CAS 39793-31-2 - Calbiochem

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