merck millipore,默克密理愽
  • merck millipore,默克密理博,14-329M,JNK2α2/SAPK1a Protein, active, 250 µg

  • merck millipore,默克密理博,14-329M,JNK2α2/SAPK1a Protein, active, 250 µg

    产品名称：JNK2α2/SAPK1a Protein, active, 250 µg
    产品型号：14-329M
    Active, N-terminal His-tagged, full length human JNK2α2/SAPK1a, for use in Kinase Assays.

    merck millipore,默克密理博,14-329M,JNK2α2/SAPK1a Protein, active, 250 µg

  • 产品介绍
  • merck millipore,默克密理博,14-329M,JNK2α2/SAPK1a Protein, active, 250 µg

    描述
    产品目录编号 14-329M
    品牌系列 Upstate
    商名
    • Upstate
    描述 JNK2α2/SAPK1a Protein, active, 250 µg
    概述 N-terminal His-tagged, full length human JNK2α2/SAPK1a
    应用
    应用 Active, N-terminal His-tagged, full length human JNK2α2/SAPK1a, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Expressed in Sf21 cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_139070.1
    • NM_002752.3
    • NM_139068.1
    • NM_139069.1
    Entrez基因汇总 The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
    基因符号
    • JNK2A
    • MAPK9
    • JNK2B
    • JNK-55
    • JNK2
    • JNK2BETA
    • p54aSAPK
    • JNK2ALPHA
    • PRKM9
    蛋白靶 JNK2α2/SAPK1a
    纯化方法 Ni2+/NTA-agarose
    靶子系列 CMGC
    UniProt编号
    • P45984
    UniProt汇总 FUNCTION: SwissProt: P45984 # JNK2 isoforms display different binding patterns: alpha- 1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.
    COFACTOR: Magnesium.
    SIZE: 424 amino acids; 48139 Da
    SUBUNIT: Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway.
    DOMAIN: SwissProt: P45984 The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
    PTM: Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme. Autophosphorylated in vitro.
    SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Routinely evaluated by phosphorylation of ATF2 (amino acids 19-96)
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 250 µg
    包装 Also available in 10 μg size (cat#14-329) and in bulk (cat# 14-329-K).

    merck millipore,默克密理博,14-329M,JNK2α2/SAPK1a Protein, active, 250 µg

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