merck millipore,默克密理愽
  • merck millipore,默克密理博,AB2290A4,Anti-MAP2, Alexa Fluor 488 Conjugate Antibody

  • merck millipore,默克密理博,AB2290A4,Anti-MAP2, Alexa Fluor 488 Conjugate Antibody

    产品名称：Anti-MAP2, Alexa Fluor 488 Conjugate Antibody
    产品型号：AB2290A4
    This Anti-MAP2, Alexa Fluor 488 Conjugate Antibody is validated for use in ICC, IHC for the detection of MAP2.

    merck millipore,默克密理博,AB2290A4,Anti-MAP2, Alexa Fluor 488 Conjugate Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB2290A4,Anti-MAP2, Alexa Fluor 488 Conjugate Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    RIHC, ICCRbAlexaFluor®488Polyclonal Antibody
    描述
    产品目录编号 AB2290A4
    描述 Anti-MAP2, Alexa Fluor® 488 Conjugate Antibody
    Alternate Names
    • MAP2
    • Microtubule-associated protein 2
    • MAP-2
    背景信息 The microtubule-associated protein 2 (MAP-2) is an abundant neuronal cytoskeletal protein that binds to tubulin, stabilizes microtubules (Herzog and Weber, 1978), and is an excellent marker for neurons. MAP-2 is essential for the development and maintenance of neuronal morphology (Matus, 1991). Three primary isoforms of MAP-2, the high molecular weight MAP2a and MAP2b, and the low molecular weight MAP2c (resulting from alternate splicing of the MAP2 gene), have been identified in neurours. (Chung et al., 1996). The low molecular weight isoform, MAP2c, is expressed in developing brain and is down-regulated during brain maturation, whereas the high molecular weight MAP2b is expressed in both developing and adult brain. The MAP2a appears only after brain maturation (Tucker, 1990). All these forms bind to microtubules through a domain near the carboxyl terminus that contains either three or four similar repeats of a 31-amino-acid motif (Lewis et al., 1988). MAP-2 together with MAP-4 and tau proteins belong to the family of thermostable proteins associated with microtubules.
    产品信息
    格式 AlexaFluor®488
    控制
    • Rat E18 cortex cells
    演示 Purified rabbit polyclonal conjugated to Alexa Fluor® 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.
    应用
    应用 This Anti-MAP2, Alexa Fluor 488 Conjugate Antibody is validated for use in ICC, IHC for the detection of MAP2.
    主要应用
    • Immunohistochemistry
    • Immunocytochemistry
    生物信息
    免疫原品种 Three KLH-conjugated linear peptides corresponding to the N-terminal and central regions of rat MAP-2.
    宿主 Rabbit
    品种反应性 Rat
    Species Reactivity Note Demonstrated to react with Rat and Mouse.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_037198
    Entrez基因汇总 Regulates and organizes microtubules; may serve as a scaffolding protein for neuromodulatory activities [RGD].
    基因符号
    • Mtap2
    • Map2
    纯化方法 Affinity purified
    UniProt编号
    • P15146
    UniProt汇总 FUNCTION: The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

    SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton probable.

    DEVELOPMENTAL STAGE: Isoform MAP2C is expressed during embryonic brain development and until postanatal day 10. Isoform MAP2B is expressed throughout brain development.

    PTM: Phosphorylated upon DNA damage, probably by ATM or ATR, by similarity. MAP2A/c is phosphorylated.

    SEQUENCE SIMILARITIES: Contains 4 Tau/MAP repeats.
    产品使用声明
    质量保证 Evaluated by Immunocytochemistry in rat E18 cortex cells.

    Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected MAP2 in rat E18 cortex cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB2290A4,Anti-MAP2, Alexa Fluor 488 Conjugate Antibody

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