merck millipore,默克密理愽
  • merck millipore,默克密理博,CC1092,Integrin α3β1, Octyl-β-D-glucopyranoside Formulation, Human

  • merck millipore,默克密理博,CC1092,Integrin α3β1, Octyl-β-D-glucopyranoside Formulation, Human

    产品名称：Integrin α3β1, Octyl-β-D-glucopyranoside Formulation, Human
    产品型号：CC1092


    merck millipore,默克密理博,CC1092,Integrin α3β1, Octyl-β-D-glucopyranoside Formulation, Human

  • 产品介绍
  • merck millipore,默克密理博,CC1092,Integrin α3β1, Octyl-β-D-glucopyranoside Formulation, Human

    描述
    产品目录编号 CC1092
    Replaces CC1029
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Integrin α3β1, Octyl-β-D-glucopyranoside Formulation, Human
    概述 Integrin alpha3beta1 was purified from human placenta by affinity chromatography using immobilized monoclonal antibodies to alpha3beta1 integrin.
    产品信息
    演示 Purified protein in 150 Mm NaCl, 0.1 mM CaCl2, 1 mM MgCl2, 25 mM Tris-HCL, pH 7.4, 100 mM Octyl-b-D-glucopyranoside. No preservatives.
    应用
    主要应用
    • Activity Assay
    • ELISA
    • Western Blotting
    应用说明 Electrophoresis, Immunoblotting, and Ligand Binding studies.

    Optimal working dilutions must be determined by end user.
    生物信息
    纯度 >95% by SDS-PAGE
    品种 Human
    Entrez基因编号
    • NM_005501.1
    • NM_002204.1
    Entrez基因汇总 ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular-matrix proteins. The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3').
    基因符号
    • CD49C
    • ITGA3
    • GAP-B3
    • CD49c
    • FLJ34704
    • MSK18
    • VLA3a
    • VL3A
    • VCA-2
    • FLJ34631
    • FRP-2
    • GAPB3
    UniProt编号
    • P26006
    UniProt汇总 FUNCTION: SwissProt: P26006 # Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Alpha- 3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.
    SIZE: 1066 amino acids; 118698 Da
    SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-3 associates with beta-1. Interacts with HPS5.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    TISSUE SPECIFICITY: Isoform alpha-3A is widely expressed. Isoform alpha-3B is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform alpha-3A is strongly expressed on vascular smooth muscle cells, isoform alpha-3B is detected only on endothelial vein cells.
    PTM: Isoform alpha-3A, but not isoform alpha-3B, is phosphorylated on serine residues. Phosphorylation increases after phorbol 12- myristate 13-acetate stimulation.
    SIMILARITY: SwissProt: P26006 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -70°C in undiluted aliquots. Avoid repeated freeze/ thaw cycles
    包装信息
    数量 25 µg

    merck millipore,默克密理博,CC1092,Integrin α3β1, Octyl-β-D-glucopyranoside Formulation, Human

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