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merck millipore,默克密理博,512533,MKLP-2 Inhibitor, Paprotrain - Calbiochem
产品名称：MKLP-2 Inhibitor, Paprotrain - Calbiochem
产品型号：512533
The MKLP-2 Inhibitor, Paprotrain controls the biological activity of MKLP-2. This small molecule/inhibitor is primarily used for Cell Signaling applications.
merck millipore,默克密理博,512533,MKLP-2 Inhibitor, Paprotrain - Calbiochem
- 产品介绍
重要规格表
经验配方 C₁₆H₁₁N₃ 描述 概述 A cell-permeable acrylonitrile compound that inhibits the kinesin-6 family member MKLP-2 (Mitotic kinesin-like protein 2; IC50 against basal and microtubule-/MT-stimulated ATPase activity = 1.35 and 0.83 µM, respectively) in a reversible, ATP-uncompetitive (Ki = 3.36 µM), and MT-noncompetitive (Ki = 1.6 µM) manner, with little effect against the ATPase activity of 12 other kinesins (≤20% inhibition at 50 µM), including the close related MKLP-1 and MPP1 (M-phase phosphoprotein 1). Shown to inhibit cellular Aurora B and Survivin anaphase centromere-to-spindle midzone relocation in HeLa cultures (50 µM for 8 h), but not MKLP-1- or Kif4-mediated PRC1 relocation, resulting in misaligned chromosomes (70% of total metaphase cells), multipolar spindles (14% of total metaphase cells), and eventual apoptosis. 产品目录编号 512533 品牌系列 Calbiochem®
同义词 (Z)-2-(1H-Indol-3-yl)-3-(pyridin-3-yl)acrylonitrile, PAssenger PROteins TRAnsport INhibitor, Mitotic Kinesin-Like Protein 2 Inhibitor 参考 参考 Tcherniuk, S., et al. 2010. Angew. Chem. Int. Ed. 49, 8228. 产品信息 形式 Yellow powder Hill配方 C₁₆H₁₁N₃ 化学配方 C₁₆H₁₁N₃ Molar Mass 245.3 结构配方图像 生物信息 纯度 ≥98% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Regulatory Review
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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