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merck millipore,默克密理博,506172,p38 MAP Kinase Inhibitor X, BIRB 796 - CAS 285983-48-4 - Calbiochem
产品名称：p38 MAP Kinase Inhibitor X, BIRB 796 - CAS 285983-48-4 - Calbiochem
产品型号：506172
The p38 MAP Kinase Inhibitor X, BIRB 796, also referenced under CAS 285983-48-4, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation More>>
merck millipore,默克密理博,506172,p38 MAP Kinase Inhibitor X, BIRB 796 - CAS 285983-48-4 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₃₁H₃₇N₅O₃ 285983-48-4 描述 概述 A cell-permeable pyrazolo-napthalenyl urea compound that acts as a highly potent, slowly binding (IC50 = 8 and 97 nM, respectively, against human p38α, respectively, with or without 2 h preincubation), but high affinity (t1/2 of dissociation from human p38α = 23 h), p38-selective inhibitor by simultaneously targeting the ATP-binding site and an adjacent DFG-out conformation-specific allosteric cavity. It inhibits JNK2α2 and c-Raf-1 only at much higher concentrations (IC50 = 98 nM and 1.4 µM, respectively) and displays little or no activity toward 10 other kinases (IC50 >20 µM). Shown to inhibit LPS-induced TNF-α production both in vitro (IC50 = 18 and 780 nM using THP-1 cells and in human whole blood, respectively) and in mice in vivo (by 84%; 30 mg/kg p.o.). 产品目录编号 506172 品牌系列 Calbiochem®
同义词 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl]urea, JNK Inhibitor XVII, Doramapimod, BIRB796 参考 参考 Liu. Y. and Gray, N.S., 2006. Nat. Chem. Biol. 2, 358.
Regan, J., et al. 2003. J. Med. Chem. 46, 4676.
Pargellis, C., et al. 2002. Nat. Struct. Biol. 9, 268.
Regan, J., et al. 2002. J. Med. Chem. 45, 2994.产品信息 CAS号 285983-48-4 形式 White solid Hill配方 C₃₁H₃₇N₅O₃ 化学配方 C₃₁H₃₇N₅O₃ Molar Mass 527.7 结构配方图像 生物信息 纯度 ≥99% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Regulatory Review
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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