merck millipore,默克密理愽
  • merck millipore,默克密理博,345883,GGTI-298 - CAS 180977-44-0 - Calbiochem

  • merck millipore,默克密理博,345883,GGTI-298 - CAS 180977-44-0 - Calbiochem

    产品名称：GGTI-298 - CAS 180977-44-0 - Calbiochem
    产品型号：345883
    A cell-permeable, prodrug form of the GGTase I inhibitor GGTI-297.

    merck millipore,默克密理博,345883,GGTI-298 - CAS 180977-44-0 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,345883,GGTI-298 - CAS 180977-44-0 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂7H₃3N₃O₃S180977-44-0
    描述
    概述 A cell-permeable, prodrug form of the GGTase I inhibitor GGTI-297 (Cat. No. 345882). Inhibits the processing of Rap 1A (IC50 = 3 µM) but has no effect on the processing of H-Ras even at concentrations of 15 µM. Inhibits PDGF-receptor tyrosine phosphorylation. Also arrests cells in the G0/G1 phase of the cell cycle, induces apoptosis, and enhances iNOS induction by IL-1β.
    产品目录编号 345883
    品牌系列 Calbiochem®
    同义词 N-4-[2(R)-Amino-3-mercaptopropyl]amino-2-naphthylbenzoyl-(L)-Leucine methyl ester, TFA
    参考
    参考 Qian, Y., et al. 1998. Bioorg. Med. Chem. 6, 293.
    Finder, J.D., et al. 1997. J. Biol. Chem. 272, 13484.
    Miquel, K., et al. 1997. Cancer Res. 57, 1846.
    Vogt, A., et al. 1997. J. Biol. Chem. 272, 27224.
    McGuire, T., et al. 1996. J. Biol. Chem. 271, 27402.
    Vogt, A., et al. 1996. Oncogene 13, 1991.
    产品信息
    CAS号 180977-44-0
    具有ATP竞争性 N
    形式 White solid
    配方 Supplied as a trifluoroacetate salt.
    Hill配方 C₂7H₃3N₃O₃S
    化学配方 C₂7H₃3N₃O₃S
    Molar Mass 479.6
    可逆 N
    结构配方图像
    生物信息
    主靶 Rap1a
    主靶IC50 3 µM against processing of Rap 1A
    纯度 ≥90% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Unstable in solution; reconstitute just prior to use.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,345883,GGTI-298 - CAS 180977-44-0 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,MABT26,Anti-E-cadherin Antibody, clone DECMA-1
下一件merck millipore产品：merck millipore,默克密理博,407616,IL-1R Antagonist - CAS 566914-00-9 - Calbiochem


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