merck millipore,默克密理愽
  • merck millipore,默克密理博,MABT26,Anti-E-cadherin Antibody, clone DECMA-1

  • merck millipore,默克密理博,MABT26,Anti-E-cadherin Antibody, clone DECMA-1

    产品名称：Anti-E-cadherin Antibody, clone DECMA-1
    产品型号：MABT26
    This Anti-E-cadherin Antibody, clone DECMA-1 is validated for use in WB, IH, IC, IP, FC, FUNC for the detection of E-cadherin.

    merck millipore,默克密理博,MABT26,Anti-E-cadherin Antibody, clone DECMA-1

  • 产品介绍
  • merck millipore,默克密理博,MABT26,Anti-E-cadherin Antibody, clone DECMA-1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HFC, WB, IHC, ICCRPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABT26
    描述 Anti-E-cadherin Antibody, clone DECMA-1
    Alternate Names
    • cell-CAM 120/80
    • CAM 120/80
    • CD324 antigen
    • Cadherin 1, E-cadherin (epithelial)
    • cadherin 1, type 1
    • cadherin 1, type 1, E-cadherin (epithelial)
    • calcium-dependent adhesion protein, epithelial
    背景信息 Cadherins are a family of transmembrane glycoproteins involved in Ca2+-dependent cell to cell interactions. The members of the family are differentially expressed in various tissues and function in the maintenance of tissue integrity, morphogenesis, and migration. Cadherins are divided into type I and type II subgroups. Type I cadherins include epithelial cadherin (E-cadherin), neural cadherin (N-cadherin), placental cadherin (P-cadherin) and retinal cadherin (R-cadherin). Type II include kidney cadherin (K-cadherin) and osteoblast cadherin (OB-cadherin). One of the best characterized cadherins is E-cadherin (epithelial cadherin or cadherin-1). It consists of calcium-binding extracellular domains responsible for interactions with other E-cadherin molecules on neighboring cells and interaction with integrin alphaEbeta7. The cytoplasmic domain of E-cadherin is linked to the actin cytoskeleton through cytoplasmic catenin proteins, thus establishing a complex localized to adherens junctions. In carcinomas, E-cadherin is frequently downregulated, consistent with its function of an invasion suppressor in normal epithelia.
    产品信息
    格式 Purified
    控制
    • A431 cell lysate
    演示 Purified rat monoclonal IgG1κ in buffer containing PBS without preservative.
    应用
    应用 This Anti-E-cadherin Antibody, clone DECMA-1 is validated for use in WB, IH, IC, IP, FC, FUNC for the detection of E-cadherin.
    主要应用
    • Flow Cytometry
    • Western Blotting
    • Immunohistochemistry
    • Immunocytochemistry
    应用说明 Immunohistochemistry Analysis: 1:300 dilution of this antibody has been shown to detect E-cadherin in mouse GI tract tissue.

    Inhibition: A previous lot was used by an independent laboratory in inhibion studies, blocking E-cadherin associated cell adhesion. (Vestweber, 1985)

    Flow Cytometry Analysis: A previous lot was used by an independent laboratory in flow cytometry applications. (Tang, 1994)
    生物信息
    免疫原品种 Mouse embryonal carcinoma cell line PCC4
    克隆 Decma-1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rat
    同种型 IgG1κ
    品种反应性 MouseHuman
    Species Reactivity Note Demonstrated to react with human and mouse.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_033994
    基因符号
    • uvomorulin
    • Arc-1
    • CD324
    • CDHE
    • Cadherin-1
    • E-cadherin
    • ECAD
    • LCAM
    • UVO
    • Uvomorulin
    纯化方法 Protein G
    UniProt编号
    • P09803
    UniProt汇总 FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 (by similarity).

    E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production (by similarity).

    SUBUNIT STRUCTURE: Homodimer; disulfide-linked. Interacts directly, via the cytoplasmic domain, with CTNNB1 or JUP to form the PSEN1/cadherin/catenin adhesion complex which connects to the actin skeleton through the actin binding of alpha-catenin. Interaction with PSEN1, cleaves CDH1 resulting in the disassociation of cadherin-based adherens junctions (CAJs). Interacts with AJAP1, CTNND1 and DLGAP5 (by similarity).

    SUBCELLULAR LOCATION: Cell junction. Cell membrane; Single-pass type I membrane protein. Note: Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm (by similarity).

    TISSUE SPECIFICTY: Non-neural epithelial tissues.

    DEVELOPMENTAL STAGE: In the testis, expression is highest in fetal gonad, then decreases 5-fold in newborn. Detectable in 7-day-old but not in 21-day-old or adult.

    SEQUENCE SIMILARITIES: Contains 5 cadherin domains.
    产品使用声明
    质量保证 Evaluated by Western Blot in A431 cell lysate.

    Western Blot Analysis: 1 µg/mL of this antibody detected E-Cadherin in 10 µg of A431 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.
    Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABT26,Anti-E-cadherin Antibody, clone DECMA-1

上一件merck millipore产品：merck millipore,默克密理博,525185,Phospholipase C Activator, m-3M3FBS - CAS 200933-14-8 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,345883,GGTI-298 - CAS 180977-44-0 - Calbiochem


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