merck millipore,默克密理愽
  • merck millipore,默克密理博,AB9348,Anti-Myelin Basic Protein Antibody

  • merck millipore,默克密理博,AB9348,Anti-Myelin Basic Protein Antibody

    产品名称：Anti-Myelin Basic Protein Antibody
    产品型号：AB9348
    Anti-Myelin Basic Protein Antibody detects level of Myelin Basic Protein & has been published & validated for use in IC, IH.

    merck millipore,默克密理博,AB9348,Anti-Myelin Basic Protein Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB9348,Anti-Myelin Basic Protein Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HIHC, ICCChAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB9348
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Myelin Basic Protein Antibody
    产品信息
    格式 Affinity Purified
    演示 Affinity purified chicken IgY. Liquid in PBS, pH 7.2 with 0.02% sodium azide.
    应用
    应用 Anti-Myelin Basic Protein Antibody detects level of Myelin Basic Protein & has been published & validated for use in IC, IH.
    主要应用
    • Immunohistochemistry
    • Immunocytochemistry
    应用说明 Immunohistochemistry: 1:50-1:100 using 2% paraformaldehyde fixed tissues.

    Immunocytochemistry: 1:50-1:100 using 2% paraformaldehyde fixed cells.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Synthetic peptide from human/mouse MBP.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Chicken
    特异性 Recognizes Myelin Basic Protein (MBP).
    品种反应性 MouseHuman
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_002385.2
    • NM_001025094.1
    • NM_001025098.1
    • NM_001025081.1
    • NM_001025090.1
    • NM_001025092.1
    • NM_001025100.1
    • NM_001025101.1
    Entrez基因汇总 The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.
    基因符号
    • Golli-mbp
    • MBP
    • MGC99675
    UniProt编号
    • P02686
    UniProt汇总 FUNCTION: SwissProt: P02686 # The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined to optional post-translational modifications give a wide spectrum of isomers, each of them having maybe a specialized function. Induces T-cell proliferation.
    SIZE: 304 amino acids; 33117 Da
    SUBUNIT: Homodimer; isoform 3 exists as a homodimer.
    SUBCELLULAR LOCATION: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin.
    TISSUE SPECIFICITY: MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system.DEVELOPMENTAL STAGE: Expression turns on abruptly in fetus of 14 to 16 weeks. Even smaller isoforms seem to be produced during embryogenesis, some of these persisting in the adult. Expression of isoform MBP2 is more evident at 16 weeks and its relative proportion declined thereafter.
    PTM: Several charge isomers of MBP; C1 (the most cationic, least modified, and most abundant form), C2, C3, C4, C5, C6, C7, C8-A and C8-B (the least cationic form); are produced as a result of optional PTM, such as phosphorylation, deamidation of glutamine or asparagine, arginine citrullination and methylation. C8-A and C8-B contain each two mass isoforms termed C8-A(H), C8-A(L), C8-B(H) and C8-B(L), (H) standing for higher and (L) for lower molecular weight. C3, C4 and C5 are phosphorylated. The ratio of methylated arginine residues decreases in aging, making the protein more cationic. & The N-terminal alanine is acetylated (isoform 3, isoform 4, isoform 5 and isoform 6). & Arg-241 was found to be 6% monomethylated and 60% symmetrically dimethylated.
    DISEASE: SwissProt: P02686 # The reduction in the surface charge of citrullinated and/or methylated MBP could result in a weakened attachment to the myelin membrane. This mechanism could be operative in demyelinating diseases such as chronical multiple sclerosis (MS), and fulminating MS (Marburg disease).
    SIMILARITY: SwissProt: P02686 ## Belongs to the myelin basic protein family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt. It is recommended that you store the antibody in the dark.
    包装信息
    数量 500 µL

    merck millipore,默克密理博,AB9348,Anti-Myelin Basic Protein Antibody

上一件merck millipore产品：merck millipore,默克密理博,14-462,Rsk3 Protein, active, 10 µg
下一件merck millipore产品：merck millipore,默克密理博,MAB5294-60UL,Anti-Neurofilament 70 kDa Antibody, clone DP5 2.7.3


相关产品

merck millipore,默克密理博,05-224,Anti-p53 Antibody, clone BP53-12 merck millipore,默克密理博,05-224,Anti-p53 Antibody, clone BP53-12

merck millipore,默克密理博,03-245,RIPAb+™ Hexim 2 - RIP Validated Antibody and Primer Set merck millipore,默克密理博,03-245,RIPAb+™ Hexim 2 - RIP Validated Antibody and Primer Set

merck millipore,默克密理博,AB3541,Anti-Tet Repressor Antibody merck millipore,默克密理博,AB3541,Anti-Tet Repressor Antibody

merck millipore,默克密理博,MABN304,Anti-Monoamine oxidase type B(MAO-B) Antibody, clone 3F12/G10/2E3 merck millipore,默克密理博,MABN304,Anti-Monoamine oxidase type B(MAO-B) Antibody, clone 3F12/G10/2E3

merck millipore,默克密理博,14-462,Rsk3 Protein, active, 10 µg merck millipore,默克密理博,14-462,Rsk3 Protein, active, 10 µg

merck millipore,默克密理博,MAB5294-60UL,Anti-Neurofilament 70 kDa Antibody, clone DP5 2.7.3 merck millipore,默克密理博,MAB5294-60UL,Anti-Neurofilament 70 kDa Antibody, clone DP5 2.7.3

merck millipore,默克密理博,MAB3468,Anti-β Galactosidase Antibody, clone DC1-4C7 merck millipore,默克密理博,MAB3468,Anti-β Galactosidase Antibody, clone DC1-4C7

merck millipore,默克密理博,06-566,Anti-Csk Antibody merck millipore,默克密理博,06-566,Anti-Csk Antibody

merck millipore,默克密理博,12-151,PKA Inhibitor peptide merck millipore,默克密理博,12-151,PKA Inhibitor peptide

merck millipore,默克密理博,506172,p38 MAP Kinase Inhibitor X, BIRB 796 - CAS 285983-48-4 - Calbiochem merck millipore,默克密理博,506172,p38 MAP Kinase Inhibitor X, BIRB 796 - CAS 285983-48-4 - Calbiochem


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部