merck millipore,默克密理愽
  • merck millipore,默克密理博,488004,Nodinitib-1 - Calbiochem

  • merck millipore,默克密理博,488004,Nodinitib-1 - Calbiochem

    产品名称：Nodinitib-1 - Calbiochem
    产品型号：488004
    A cell-permeable aminobenzimidazole compound that acts as a potent, specific and reversible inhibitor of NOD1-induced NF-κB activation.

    merck millipore,默克密理博,488004,Nodinitib-1 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,488004,Nodinitib-1 - Calbiochem

    重要规格表

    经验配方
    C₁₄H₁₃N₃O₂S
    描述
    概述 A cell-permeable aminobenzimidazole compound that acts as a potent, specific and reversible inhibitor of NOD1 (Nucleotide-binding Oligomerization Domain 1; NLRC1, CARD4, or CLR7.1)-induced NF-κB activation (IC50 = 0.56 µM, >20, and >20 by NOD1 ligand, NOD2 ligand and TNFα in HEK293T-NF-κB-luciferase cells, respectively). Shown to block phosphorylation and degradation of IκBα and MAPK signaling (5 µM in HCT-116 cells) with no effect on Akt pathway. Suggested to directly interact with NOD1, alter the conformation and suppress RIP2 trafficking, a NOD1-binding partner required for NF-κB induction.
    产品目录编号 488004
    品牌系列 Calbiochem®
    同义词 CID-1088438, 1-((4-Methylphenyl)sulfonyl)-1H-benzimidazol-2-amine, ML130, 1-(Toluene-4-sulfonyl)-1H-benzimidazol-2-ylamine, NOD1 Signaling Inhibitor, Nucleotide-binding Oligomerization Domain 1 Signaling Inhibitor
    参考
    参考 Khan, P.M., et al. 2011. ACS Med. Chem. Lett. 2, 780.
    Correa, R.G., et al. 2011. Chem. Biol. 18, 825.
    产品信息
    形式 White powder
    Hill配方 C₁₄H₁₃N₃O₂S
    化学配方 C₁₄H₁₃N₃O₂S
    Molar Mass 287.3
    结构配方图像
    生物信息
    纯度 ≥99% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,488004,Nodinitib-1 - Calbiochem

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下一件merck millipore产品：merck millipore,默克密理博,566326,SIRT2 Inhibitor, Inactive Control, AGK7 - CAS 304896-21-7 - Calbiochem


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