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merck millipore,默克密理博,MAB2263,Anti-GluR1-NT (NT) Antibody, clone RH95
产品名称：Anti-GluR1-NT (NT) Antibody, clone RH95
产品型号：MAB2263
Anti-GluR1-NT (N-terminus) Antibody, clone RH95 is an antibody against GluR1-NT (N-terminus) for use in WB, IP, IC, ELISA.
merck millipore,默克密理博,MAB2263,Anti-GluR1-NT (NT) Antibody, clone RH95
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R ELISA, WB, ICC M Purified Monoclonal Antibody 描述 产品目录编号 MAB2263 描述 Anti-GluR1-NT (NT) Antibody, clone RH95 Alternate Names - glutamate receptor, ionotropic, AMPA 1
- AMPA 1
- AMPA-selective glutamate receptor 1
- Glutamate receptor ionotropic, AMPA 1
背景信息 Glutamate receptors (GluRs) are a diverse group responsible for mediating most of the excitatory synaptic transmission in the CNS of vertebrates. They can be categorized as ionotropic or metabotropic and subcategorized by their agonist preferences (NMDA, AMPA or Kainic acid). There are four types of AMPA selective GluR subunits (GluR1, GluR2, GluR3 and GluR4). Tetrameric or pentameric combinations of different subunits contributes to the functional diversity of AMPA receptors. AMPA receptors mediate fast synaptic current at most excitatory synapses, with stoichiometry characterized by subtype composition. The critical residue controlling calcium permeability is in the pore loop region. In GluR1, GluR3, and GluR4, this position is occupied by a Gln residue. The insertion or removal of GluR1/GluR4 oligomeric channels from postsynaptic membranes appears to be LTP/LTD activity dependent while GluR2/GluR3 oligomers are continuously cycling. 产品信息 格式 Purified 控制 - Rat brain lysate
演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 Anti-GluR1-NT (N-terminus) Antibody, clone RH95 is an antibody against GluR1-NT (N-terminus) for use in WB, IP, IC, ELISA. 主要应用 - ELISA
- Western Blotting
- Immunocytochemistry
生物信息 免疫原品种 Thyroglobulin-conjugated linear peptide of rat GluR1 designed around the N-terminus. 表位 N-terminus 克隆 RH95 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody recognizes GluR1 at the N-terminus. 同种型 IgG2aκ 品种反应性 Rat Species Reactivity Note Proven to react with rat. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_113796.1
Entrez基因汇总 Mouse homolog may play a role in regulation of neuronal synaptic plasticity and conditioned reinforcement learning. [RGD] 基因符号 - GRIA1
- GLUH1
- GLUR1
- GLURA
- GluR-1
- GluR-A
- GluR-K1
- HBGR1
- MGC133252
纯化方法 Protein G purfied UniProt编号 - P19490
UniProt汇总 FUNCTION: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
SUBUNIT STRUCTURE: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with DLG1 via its C-terminus. Interacts with CACNG2, HIP1 and probably RASGRF2.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Note: Interaction with CACNG2 promotes cell surface expression.
TISSUE SPECIFICITY: Detected in cerebellum (at protein level).
PTM: Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis By similarity.
POLYMORPHISM: Both variants Ser-710 and Thr-710 are phosphorylated at this position.
MISCELLANEOUS: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.
SEQUENCE SIMILARITIES: Belongs to the glutamate-gated ion channel (TC 1.A.10) family. [View classification]产品使用声明 质量保证 Evaluated by Western Blot in rat brain lysate.
Western Blot Analysis: A 1:1000 dilutions of this antibody detected GluR1 in 10 µg of rat brain lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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