merck millipore,默克密理愽
  • merck millipore,默克密理博,04-322,Anti-Acetyl CoA Carboxylase 1 Antibody, rabbit monoclonal

  • merck millipore,默克密理博,04-322,Anti-Acetyl CoA Carboxylase 1 Antibody, rabbit monoclonal

    产品名称：Anti-Acetyl CoA Carboxylase 1 Antibody, rabbit monoclonal
    产品型号：04-322
    Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-Acetyl CoA Carboxylase 1 Antibody, Rabbit detec More>>

    merck millipore,默克密理博,04-322,Anti-Acetyl CoA Carboxylase 1 Antibody, rabbit monoclonal

  • 产品介绍
  • merck millipore,默克密理博,04-322,Anti-Acetyl CoA Carboxylase 1 Antibody, rabbit monoclonal

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWBRbPurifiedMonoclonal Antibody
    描述
    产品目录编号 04-322
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-Acetyl CoA Carboxylase 1 Antibody, rabbit monoclonal
    Alternate Names
    • ACACA, ACAC, ACC, ACC1, ACCA, acetyl-Coenzyme A carboxylase alpha
    • ACACA
    • ACAC
    • ACC
    • ACC1
    • ACCA
    产品信息
    格式 Purified
    演示 100 μL of rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 0.09 M NaCl, 0.006% sodium azide, 0.03% BSA and 40% glycerol.
    应用
    应用 Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-Acetyl CoA Carboxylase 1 Antibody, Rabbit detects level of Acetyl CoA Carboxylase 1 & has been published & validated for use in WB, IH(P).
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated synthetic peptide corresponding to human Acetyl CoA Carboxylase 1
    宿主 Rabbit
    特异性 Recognizes Acetyl CoA Carboxylase 1
    品种反应性 RatHumanMouse
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_198839.1
    • NM_198834.1
    • NM_198836.1
    • NM_198837.1
    • NM_198838.1
    Entrez基因汇总 Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
    基因符号
    • ACAC
    • ACACA
    • ACC-alpha
    • ACCA
    • ACC
    • ACC1
    UniProt编号
    • Q13085
    UniProt汇总 FUNCTION: SwissProt: Q13085 # Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
    COFACTOR: Biotin. & Binds 2 manganese ions per subunit.
    SIZE: 2346 amino acids; 265554 Da
    SUBUNIT: Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis.
    SUBCELLULAR LOCATION: Cytoplasm.
    TISSUE SPECIFICITY: Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.
    PTM: Phosphorylation on Ser-1263 is required for interaction with BRCA1.
    SIMILARITY: SwissProt: Q13085 ## Contains 1 ATP-grasp domain. & Contains 1 biotin carboxylation domain. & Contains 1 biotinyl-binding domain. & Contains 1 carboxyltransferase domain.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 2 years at -20°C from date of shipment.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,04-322,Anti-Acetyl CoA Carboxylase 1 Antibody, rabbit monoclonal

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