merck millipore,默克密理愽
  • merck millipore,默克密理博,444290,MMP Inhibitor V - CAS 223472-31-9 - Calbiochem

  • merck millipore,默克密理博,444290,MMP Inhibitor V - CAS 223472-31-9 - Calbiochem

    产品名称：MMP Inhibitor V - CAS 223472-31-9 - Calbiochem
    产品型号：444290
    The MMP Inhibitor V, also referenced under CAS 223472-31-9, controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

    merck millipore,默克密理博,444290,MMP Inhibitor V - CAS 223472-31-9 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,444290,MMP Inhibitor V - CAS 223472-31-9 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₂H₂₈N₂O₆223472-31-9
    描述
    概述 An orally active non-peptidyl hydroxamate compound that acts as an effective broad-spectrum inhibitor against MMP-2, -3, -8, -9, -12, -13 (Ki = 0.73, 42, 1.1, 2.1, 0.45, and 1.1 nM, respectively), but not MMP-1 (IC50 = 1.6 µM), MMP-7 (Ki = 2.5 µM), or other serine proteases (no activity against chymotrypsin or plasmin at 100 µM). Widely used in studying MMP-mediated diseases development in vivo. Also reported to block P-LAP secretase activity (≥70% inhibition of P-LAP shedding at 10 µM) that is otherwise not inhibited by TIMP-1/2 in CHO cell cultures in vitro.
    产品目录编号 444290
    品牌系列 Calbiochem®
    同义词 (2S,4S)-N-Hydroxy-5-ethoxymethyloxy-2-methyl-4-(4-phenoxybenzoyl)aminopentanamide, ONO-4817
    参考
    参考 Okamoto, Y., et al. 2007. Int. Heart J. 48, 369.
    Ito, N., et al. 2004. Biochem. Biophys. Res. Commun. 314, 1008.
    Shiraga, M., et al. 2002. Cancer Res. 62, 5967.
    Mori, T., et al. 2001. Exp. Biol. Med. 226, 429.
    Yamada, A., et al. 2000. Inflamm. Res. 49, 144.
    产品信息
    CAS号 223472-31-9
    形式 Off-white solid
    Hill配方 C₂₂H₂₈N₂O₆
    化学配方 C₂₂H₂₈N₂O₆
    Molar Mass 446.5
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,444290,MMP Inhibitor V - CAS 223472-31-9 - Calbiochem

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