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经验配方 CAS号 C₁₄H₁₆N₂O₃S 254753-54-3 描述 概述 A potent, cell-permeable, non-tubulin-interacting mitosis inhibitor. Arrests mammalian cells in mitosis with monopolar spindles. In vitro, it specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein involved in the assembly and maintenance of the mitotic spindle (IC50 = 14 µM). 产品目录编号 475879 品牌系列 Calbiochem®
同义词 4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic Acid Ethyl Ester, Eg5 Inhibitor I 参考 参考 Kapoor, T.M., et al. 2000. J. Cell Biol. 150, 975.
Mayer, T.U., et al. 1999. Science 286, 971.产品信息 CAS号 254753-54-3 具有ATP竞争性 N 形式 White solid Hill配方 C₁₄H₁₆N₂O₃S 化学配方 C₁₄H₁₆N₂O₃S Molar Mass 292.4 可逆 N 结构配方图像 生物信息 主靶 Mitotic kinesin Eg5 主靶IC50 14 µM against mitotic kinesin Eg5 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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